INT272479

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Context Info
Confidence 0.50
First Reported 2008
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.45
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Dmpk) mitochondrion (Dmpk) endoplasmic reticulum (Dmpk)
plasma membrane (Dmpk) nucleus (Dmpk) kinase activity (Dmpk)
Dmpk (Mus musculus)
Pain Link Frequency Relevance Heat
abdominal pain 2 37.40 Quite Low
Kinase C 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
spastic colon 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 39 80.80 Quite High
Toxicity 20 69.92 Quite High
Myotonic Dystrophy 38 67.88 Quite High
Myotonic Disorders 3 66.68 Quite High
Frailty 13 44.88 Quite Low
Dysphagia 2 38.24 Quite Low
Abdominal Pain 2 37.40 Quite Low
Fatigue 3 36.76 Quite Low
Sleep Disorders 4 36.00 Quite Low
Hypopituitarism 22 34.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since the discovery of the genetic mutation responsible for DM1, much effort has been devoted to precisely define whether DMPK transcripts and/or protein levels change in the presence of CTG expansions.
Spec (whether) Regulation (change) of DMPK
1) Confidence 0.50 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0.06 Pain Relevance 0
No significant changes in the mutant DMPK mRNA stability and polyadenylation have been found [36].
Neg (No) Regulation (changes) of mutant DMPK mRNA
2) Confidence 0.21 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.07 Pain Relevance 0
In this present review, we will specifically focus on the levels of gene expression regulation that mutant DMPK affects, namely gene transcription, alternative splicing, gene silencing and RNA translation, with particular emphasis on recent data.


Regulation (affects) of DMPK
3) Confidence 0.19 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0.32 Pain Relevance 0

General Comments

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