INT272480

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Context Info
Confidence 0.40
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Mef2a) nucleus (Mef2a) DNA binding (Mef2a)
Anatomy Link Frequency
myoblasts 1
Mef2a (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 10 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Left Ventricular Hypertrophy 10 50.00 Quite Low
Myotonic Dystrophy 8 50.00 Quite Low
Disease 13 25.60 Quite Low
Tremor 1 23.44 Low Low
Ataxia 2 22.88 Low Low
Syndrome 1 22.32 Low Low
Disorder Of Lipid Metabolism 1 16.40 Low Low
Coronary Heart Disease 13 8.44 Low Low
Hypopituitarism 11 5.00 Very Low Very Low Very Low
Fibrosis 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The treatment with siMEF2C was accompanied by marked reduction of MEF2C transcripts, but not of those from MEF2A, MEF2B or MEF2D (Figure 2C-F), after normalization to GAPDH.
Negative_regulation (reduction) of MEF2A
1) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0 Pain Relevance 0
Because examination of DM1 cells revealed that both cyclin D3 and cdk4 levels did not increase in DM1 differentiating cells, reduction in formation of the translational complex CUG-BP1-eIF2 provides a reasonable explanation for the reduction in p21 and Mef2A translation in DM1 myoblasts.
Negative_regulation (reduction) of Mef2A in myoblasts
2) Confidence 0.10 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0 Pain Relevance 0

General Comments

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