INT272484

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Context Info
Confidence 0.39
First Reported 2007
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 8
Total Number 11
Disease Relevance 6.77
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Myod1) nucleus (Myod1) enzyme binding (Myod1)
DNA binding (Myod1) transcription factor binding (Myod1) cytoplasm (Myod1)
Anatomy Link Frequency
muscle 2
skeletal muscle 2
ligament 1
myoblasts 1
gastrocnemius 1
Myod1 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 40 85.24 High High
cytokine 34 68.04 Quite High
Pain 4 67.88 Quite High
vincristine 1 14.48 Low Low
Inflammation 36 5.00 Very Low Very Low Very Low
Osteoarthritis 12 5.00 Very Low Very Low Very Low
tolerance 8 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rhabdomyosarcoma 8 99.56 Very High Very High Very High
Lymphatic System Cancer 3 99.40 Very High Very High Very High
Targeted Disruption 19 98.24 Very High Very High Very High
Hypopituitarism 11 96.44 Very High Very High Very High
Atrophic Muscular Disorders 1 96.40 Very High Very High Very High
Muscular Atrophy 46 96.12 Very High Very High Very High
Synovial Sarcoma 5 94.20 High High
Muscular Dystrophy 208 94.04 High High
Muscle Disease 89 93.48 High High
Neuroendocrine Cancer 2 93.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression levels of Col1a1 (a positive marker for tendon, ligament and skeletal muscle), Col2a1 (a negative marker for the same tissues), Myod1 (a positive marker for skeletal muscle and a negative marker for tendon) and Comp were determined at 3 weeks of age by quantitative real-time PCR (Supplementary Material, Table S1).
Spec (determined) Negative_regulation (levels) of Myod1 in ligament
1) Confidence 0.39 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.27 Pain Relevance 0
In the MyoD knockout skeletal muscle forms normally, this is because there is compensation from the other members of the MyoD family of transcription factors that are able to substitute for the loss of MyoD.
Negative_regulation (loss) of MyoD in skeletal muscle associated with targeted disruption
2) Confidence 0.37 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC3024556 Disease Relevance 0.74 Pain Relevance 0.06
MyoD levels, previously reported to be reduced in the muscle of AH-130 bearers [20], are unaffected in the gastrocnemius of the C26 hosts (Fig. 5B), while the marked decrease of myogenin is rescued by PD treatment (Fig. 5B).
Negative_regulation (reduced) of MyoD in gastrocnemius
3) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965098 Disease Relevance 0.60 Pain Relevance 0
combined developed muscle hypotrophy, associated with decreased MyoD levels, through a mechanism involving NF-?
Negative_regulation (decreased) of MyoD in muscle
4) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965098 Disease Relevance 0.58 Pain Relevance 0.03
This decline in regenerating capacity was possibly related to an accelerated breakdown of MyoD by the ubiquitin proteasome pathway (Langen et al 2004).
Negative_regulation (breakdown) of MyoD
5) Confidence 0.15 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695204 Disease Relevance 0.73 Pain Relevance 0
Levels of MyoD, a TF necessary for muscle differentiation and regeneration, are significantly reduced in myoblasts expressing the mutant 3'-UTR DMPK RNA [41].
Negative_regulation (reduced) of MyoD in myoblasts
6) Confidence 0.13 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0.15 Pain Relevance 0
The expression levels of Col1a1 (a positive marker for tendon, ligament and skeletal muscle), Col2a1 (a negative marker for the same tissues), Myod1 (a positive marker for skeletal muscle and a negative marker for tendon) and Comp were determined at 3 weeks of age by quantitative real-time PCR (Supplementary Material, Table S1).
Spec (determined) Negative_regulation (levels) of Myod1 in skeletal muscle
7) Confidence 0.13 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.27 Pain Relevance 0
The expression levels of Col1a1 (a positive marker for tendon, ligament and skeletal muscle), Col2a1 (a negative marker for the same tissues), Myod1 (a positive marker for skeletal muscle and a negative marker for tendon) and Comp were determined at 3 weeks of age by quantitative real-time PCR (Supplementary Material, Table S1).
Spec (determined) Negative_regulation (levels) of Myod1 in tendon
8) Confidence 0.13 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.27 Pain Relevance 0
During differentiation, phosphorylated ERK, occurring at high levels over days 1–3, progressively declines concomitantly with Pax7 reduction and myogenin and MyoD increases (Fig.
Negative_regulation (reduction) of MyoD
9) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965098 Disease Relevance 0.27 Pain Relevance 0
Researchers have therefore increased the severity of the murine dystrophin-deficiency phenotype by creating double mutants: either mice lacking both dystrophin and its paralogue, utrophin, or both dystrophin and MyoD (a transcription factor important in muscle development and regeneration) [18], [26].
Negative_regulation (lacking) of MyoD in muscle
10) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2800183 Disease Relevance 0.54 Pain Relevance 0.04
However, the lack of desmin, myogenin and MyoD-1 ruled out rhabdomyosarcoma, while LCA negativity ruled out a diagnosis of lymphoma.
Negative_regulation (lack) of MyoD-1 associated with lymphatic system cancer and rhabdomyosarcoma
11) Confidence 0.02 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2848680 Disease Relevance 2.36 Pain Relevance 0.07

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