INT272485

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.50
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.56
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Dmpk) mitochondrion (Dmpk) endoplasmic reticulum (Dmpk)
plasma membrane (Dmpk) nucleus (Dmpk) kinase activity (Dmpk)
Anatomy Link Frequency
Posterior 2
Dmpk (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 3 55.04 Quite High
Kinase C 6 5.00 Very Low Very Low Very Low
abdominal pain 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
spastic colon 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 22 89.44 High High
Targeted Disruption 43 82.56 Quite High
Muscle Disease 3 76.48 Quite High
Arrhythmia Under Development 8 62.08 Quite High
Impaired Glucose Tolerance 3 55.68 Quite High
Disease 52 50.00 Quite Low
Myotonic Dystrophy 46 50.00 Quite Low
Myotonic Disorders 4 33.80 Quite Low
Hypopituitarism 33 29.44 Quite Low
Cv Unclassified Under Development 4 27.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Initial reports using antisera and semiquantitative reverse transcriptase-polymerase chain reaction reported decreased levels of both DMPK mRNA and protein in adult forms of DM1, suggesting that large CTG repeat expansions altered DMPK mRNA synthesis and processing [15-18].
Regulation (altered) of Transcription (synthesis) of DMPK
1) Confidence 0.50 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0 Pain Relevance 0
Although CTG repeats affect expression of DMPK protein and the transcription of genes in the DMPK locus (recently reviewed in details in [24]), multisystemic nature of DM1 is mainly associated with the accumulation of non-coding CUG repeat RNA [25-34].
Regulation (affect) of Transcription (transcription) of DMPK protein
2) Confidence 0.24 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.15 Pain Relevance 0
Posterior studies confirmed that DMPK transcription was altered in patients and that there was no correlation between CTG repeat length and DMPK protein reduction [23-25].
Regulation (altered) of Transcription (transcription) of DMPK in Posterior
3) Confidence 0.22 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0.28 Pain Relevance 0.03
However, subsequent improvements of protocols used for detection and quantification of total cytoplasmic mRNA levels reported that there was no significant change in DMPK transcription [21], and discovered that the anti-DMPK antisera used in previous reports crossreacted with other proteins [22].
Neg (no) Regulation (change) of Transcription (transcription) of DMPK
4) Confidence 0.19 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0.13 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox