INT2725

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Context Info
Confidence 0.69
First Reported 1979
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 23
Total Number 23
Disease Relevance 23.08
Pain Relevance 4.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (FCER2) plasma membrane (FCER2)
Anatomy Link Frequency
eosinophils 2
FDC 2
macrophages 1
platelets 1
blood 1
FCER2 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 6 100.00 Very High Very High Very High
Inflammatory marker 2 99.56 Very High Very High Very High
Paracetamol 7 99.34 Very High Very High Very High
endometriosis 672 98.64 Very High Very High Very High
anesthesia 2 97.96 Very High Very High Very High
abdominal pain 7 96.68 Very High Very High Very High
Pain 73 94.72 High High
Enkephalin 1 94.72 High High
cINOD 3 93.80 High High
epidural 1 90.88 High High
Disease Link Frequency Relevance Heat
Eosinophilia 27 99.96 Very High Very High Very High
Eczema 8 99.96 Very High Very High Very High
Hypergammaglobulinemia 1 99.96 Very High Very High Very High
Asthma 38 99.90 Very High Very High Very High
Ulcers 2 99.90 Very High Very High Very High
Myocardial Infarction 6 99.88 Very High Very High Very High
Infection 34 99.80 Very High Very High Very High
Cancer 31 99.76 Very High Very High Very High
INFLAMMATION 222 99.24 Very High Very High Very High
Enteritis 4 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Eosinophilia, elevated immunoglobulin E level and chronic enteritis due to intestinal helminthiasis.
Positive_regulation (elevated) of immunoglobulin E associated with helminth infection, enteritis and eosinophilia
1) Confidence 0.69 Published 1979 Journal Am. J. Med. Section Title Doc Link 507102 Disease Relevance 0.77 Pain Relevance 0.10
Laboratory findings included peripheral eosinophilia and an increased serum immunoglobulin E level.
Positive_regulation (increased) of serum immunoglobulin E associated with eosinophilia
2) Confidence 0.69 Published 2006 Journal J. Gastroenterol. Section Abstract Doc Link 16933010 Disease Relevance 0.90 Pain Relevance 0.10
Immunohistochemical staining revealed that the tumor cells were positive for CD21, CD23, CD35, and clusterin, and focally positive for CD68, CD20, and CD79a.
Positive_regulation (positive) of CD23 associated with cancer
3) Confidence 0.42 Published 2006 Journal Arch. Pathol. Lab. Med. Section Abstract Doc Link 17076538 Disease Relevance 0.51 Pain Relevance 0.13
Patients with ulcers had increased blood eosinophil, immunoglobulin E and serological values.
Positive_regulation (increased) of immunoglobulin E in eosinophil associated with ulcers
4) Confidence 0.41 Published 1996 Journal J. Gastroenterol. Hepatol. Section Abstract Doc Link 8792304 Disease Relevance 1.44 Pain Relevance 0.35
The atypical cells were immunoreactive for FDC markers such as CD21/CD35, CD23, and CNA.42.
Positive_regulation (immunoreactive) of CD23 in FDC
5) Confidence 0.40 Published 2001 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 11395549 Disease Relevance 1.60 Pain Relevance 0.22
Radioallergosorbent test results were positive to several foods, and the total serum immunoglobulin E (IgE) level was elevated.
Positive_regulation (elevated) of serum immunoglobulin E
6) Confidence 0.35 Published 2002 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 11960068 Disease Relevance 0.99 Pain Relevance 0.08
Hyper IgE recurrent infection syndrome (HIES, or Job's syndrome) is a primary immunodeficiency characterized by recurrent skin and lung infections, eczema, elevated serum immunoglobulin E (IgE) levels, and various connective tissue and skeletal system abnormalities including characteristic facies, scoliosis, joint hyperextensibility, retained primary dentition, craniosynostosis, osteopenia, and pathologic fractures.
Positive_regulation (elevated) of serum immunoglobulin E in lung associated with syndrome, spontaneous fractures, osteoporosis, eczema, infection, scoliosis, facies, craniosynostosis, congenital anomalies and immunodeficiency
7) Confidence 0.28 Published 2007 Journal Clin. Immunol. Section Abstract Doc Link 17098478 Disease Relevance 1.83 Pain Relevance 0.05
The disease is associated with eosinophilic infiltration of various layers of gastrointestinal tract along with significant peripheral eosinophilia and increased Immunoglobulin E (IgE).
Positive_regulation (increased) of Immunoglobulin E associated with rhinitis, disease and eosinophilia
8) Confidence 0.19 Published 2007 Journal J Ayub Med Coll Abbottabad Section Abstract Doc Link 18693615 Disease Relevance 0.77 Pain Relevance 0.24
Elevated levels of total immunoglobulin E were seen in 78% of patients and of Aspergillus-specific immunoglobulin E in 64%.
Positive_regulation (levels) of immunoglobulin E
9) Confidence 0.15 Published 2003 Journal Clin. Infect. Dis. Section Abstract Doc Link 12975754 Disease Relevance 1.50 Pain Relevance 0.18
Immunological serology showed an increase in eosinophils and immunoglobulin E, and a decreased reaction of lymphocyte blastoid transformation.
Positive_regulation (increase) of immunoglobulin E in lymphocyte
10) Confidence 0.11 Published 2000 Journal J Nippon Med Sch Section Abstract Doc Link 11116243 Disease Relevance 0.74 Pain Relevance 0.28
Soluble CD23, which may be derived from mature B cells and also from activated macrophages, eosinophils, follicular dendritic cells, and platelets, is increased in serum and peritoneal fluid of endometriosis patients, which may be suggestive of an exacerbated B cell activation in endometriosis [68] (Fig. 1).
Positive_regulation (increased) of CD23 in macrophages associated with endometriosis
11) Confidence 0.10 Published 2007 Journal Semin Immunopathol Section Body Doc Link PMC2668599 Disease Relevance 0.91 Pain Relevance 0.41
Hyper IgE recurrent infection syndrome (HIES, or Job's syndrome) is a primary immunodeficiency characterized by recurrent skin and lung infections, eczema, elevated serum immunoglobulin E (IgE) levels, and various connective tissue and skeletal system abnormalities including characteristic facies, scoliosis, joint hyperextensibility, retained primary dentition, craniosynostosis, osteopenia, and pathologic fractures.
Positive_regulation (elevated) of serum immunoglobulin E in skin associated with syndrome, spontaneous fractures, osteoporosis, eczema, infection, scoliosis, facies, craniosynostosis, congenital anomalies and immunodeficiency
12) Confidence 0.10 Published 2007 Journal Clin. Immunol. Section Abstract Doc Link 17098478 Disease Relevance 1.83 Pain Relevance 0.05
Soluble CD23, which may be derived from mature B cells and also from activated macrophages, eosinophils, follicular dendritic cells, and platelets, is increased in serum and peritoneal fluid of endometriosis patients, which may be suggestive of an exacerbated B cell activation in endometriosis [68] (Fig. 1).
Positive_regulation (increased) of CD23 in follicular dendritic cells associated with endometriosis
13) Confidence 0.04 Published 2007 Journal Semin Immunopathol Section Body Doc Link PMC2668599 Disease Relevance 0.91 Pain Relevance 0.41
Soluble CD23, which may be derived from mature B cells and also from activated macrophages, eosinophils, follicular dendritic cells, and platelets, is increased in serum and peritoneal fluid of endometriosis patients, which may be suggestive of an exacerbated B cell activation in endometriosis [68] (Fig. 1).
Positive_regulation (increased) of CD23 in eosinophils associated with endometriosis
14) Confidence 0.04 Published 2007 Journal Semin Immunopathol Section Body Doc Link PMC2668599 Disease Relevance 0.91 Pain Relevance 0.41
Soluble CD23, which may be derived from mature B cells and also from activated macrophages, eosinophils, follicular dendritic cells, and platelets, is increased in serum and peritoneal fluid of endometriosis patients, which may be suggestive of an exacerbated B cell activation in endometriosis [68] (Fig. 1).
Positive_regulation (increased) of CD23 in platelets associated with endometriosis
15) Confidence 0.04 Published 2007 Journal Semin Immunopathol Section Body Doc Link PMC2668599 Disease Relevance 0.91 Pain Relevance 0.41
Release can be induced via specific immunoglobulin E (IgE), components of complement activation and nonspecifically by various compounds including endogenous peptides, endorphins, and enkephalins.
Positive_regulation (induced) of immunoglobulin E associated with enkephalin
16) Confidence 0.04 Published 2006 Journal Allergy Asthma Proc Section Abstract Doc Link 16724623 Disease Relevance 0.51 Pain Relevance 0.09
METHODS: In the Avon Longitudinal Study of Parents and Children (ALSPAC), a population-based birth cohort, we compared the univariate effects of maternal use of paracetamol in pregnancy on risk of doctor-diagnosed asthma, wheeze and elevated immunoglobulin E (IgE) in the offspring at 7 years of age, with the univariate effects of partner's use and postnatal maternal use on these phenotypes.
Positive_regulation (elevated) of immunoglobulin E
17) Confidence 0.02 Published 2010 Journal Int J Epidemiol Section Body Doc Link 20356852 Disease Relevance 0 Pain Relevance 0
Prenatal paracetamol exposure and risk of asthma and elevated immunoglobulin E in childhood.
Positive_regulation (elevated) of immunoglobulin E associated with asthma, aspirin and paracetamol
18) Confidence 0.01 Published 2005 Journal Clin. Exp. Allergy Section Title Doc Link 15649261 Disease Relevance 0.10 Pain Relevance 0.35
These children will frequently have elevated levels of Immunoglobulin E (IgE).
Positive_regulation (elevated) of Immunoglobulin E
19) Confidence 0.01 Published 2010 Journal Chiropr Osteopat Section Body Doc Link PMC2891801 Disease Relevance 2.10 Pain Relevance 0.26
We report two cases of fatal cardiac arrest with increased blood tryptase and immunoglobulin E values after succinylcholine administration.
Positive_regulation (increased) of immunoglobulin E in blood associated with myocardial infarction
20) Confidence 0.01 Published 2009 Journal Anesth. Analg. Section Abstract Doc Link 19535703 Disease Relevance 0.44 Pain Relevance 0.18

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