INT272502

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.14
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DICER1) intracellular (DICER1) helicase activity (DICER1)
cytoplasm (DICER1)
DICER1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 83 100.00 Very High Very High Very High
Inflammation 36 100.00 Very High Very High Very High
Central nervous system 10 5.00 Very Low Very Low Very Low
chemokine 8 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
Multiple sclerosis 4 5.00 Very Low Very Low Very Low
Kinase C 4 5.00 Very Low Very Low Very Low
Spinal cord 3 5.00 Very Low Very Low Very Low
ischemia 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 83 100.00 Very High Very High Very High
INFLAMMATION 42 100.00 Very High Very High Very High
Neuroblastoma 11 94.96 High High
Neurodegenerative Disease 8 87.68 High High
Death 38 85.28 High High
Drug Induced Neurotoxicity 2 76.56 Quite High
Toxicity 11 76.48 Quite High
Myotonic Dystrophy 16 75.00 Quite High
Apoptosis 14 74.24 Quite High
Cataract 8 41.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At day 1 after infection no significant increase was observed in the mRNA expression of any pro-inflammatory cytokines in both MOI-1 and -5 infected cells (Figure 2A).
Transcription (expression) of MOI-1 associated with inflammation, infection and cytokine
1) Confidence 0.08 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2984415 Disease Relevance 1.99 Pain Relevance 0.39
Recently, transcripts containing long hairpin structures of CUG repeats have been shown to be a Dicer ribonuclease target and Dicer-induced downregulation of the mutant DMPK transcripts triggers silencing effects on RNAs containing long complementary repeats.
Transcription (target) of Dicer
2) Confidence 0.07 Published 2008 Journal Current Genomics Section Abstract Doc Link PMC2694559 Disease Relevance 0.07 Pain Relevance 0
Recently, transcripts containing long hairpin structures of CUG repeats have been shown to be a Dicer ribonuclease target and Dicer-induced downregulation of the mutant DMPK transcripts triggers silencing effects on RNAs containing long complementary repeats.
Transcription (target) of Dicer
3) Confidence 0.07 Published 2008 Journal Current Genomics Section Abstract Doc Link PMC2694559 Disease Relevance 0.07 Pain Relevance 0

General Comments

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