INT272508

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Context Info
Confidence 0.11
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.21
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DICER1) intracellular (DICER1) helicase activity (DICER1)
cytoplasm (DICER1)
Anatomy Link Frequency
Macrophages 1
DICER1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 3 92.08 High High
Inflammation 8 5.00 Very Low Very Low Very Low
Kinase C 4 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 44 96.88 Very High Very High Very High
Cancer 127 93.36 High High
Repression 4 91.64 High High
Apoptosis 71 82.88 Quite High
Shock 2 75.04 Quite High
Myotonic Dystrophy 16 75.00 Quite High
Germ Cell And Embryonal Neoplasms 1 73.20 Quite High
Testicular Cancer 7 66.96 Quite High
Acute Monocytic Leukemia 1 56.32 Quite High
Cataract 8 41.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Macrophages did not inhibit the expression of DR4 or DR5, or modulate the levels of decoy receptors DcR1 or DcR2 in HCT116/Hke-3 cells (Figure S1), suggesting that they do not modulate the responsiveness to TRAIL through regulation of TRAIL receptors.
Neg (not) Regulation (modulate) of DcR1 in Macrophages
1) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 0.84 Pain Relevance 0.05
Genetic studies disrupting miRNA functions in mammals by targeting Dicer, Drosha, DGCR8, or individual miRNAs have revealed specific and global roles of miRNAs a variety of developmental processes and pathologic states.
Regulation (targeting) of Dicer
2) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012074 Disease Relevance 0.30 Pain Relevance 0
Recently, transcripts containing long hairpin structures of CUG repeats have been shown to be a Dicer ribonuclease target and Dicer-induced downregulation of the mutant DMPK transcripts triggers silencing effects on RNAs containing long complementary repeats.
Regulation (target) of Dicer
3) Confidence 0.03 Published 2008 Journal Current Genomics Section Abstract Doc Link PMC2694559 Disease Relevance 0.07 Pain Relevance 0
Indeed, Krol and co-workers [90] have shown that transcripts containing long hairpin structures composed of CNG repeats are a class of Dicer ribonuclease targets.
Regulation (targets) of Dicer
4) Confidence 0.03 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0 Pain Relevance 0

General Comments

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