INT272511

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.54
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 11
Disease Relevance 6.85
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DMPK) mitochondrion (DMPK) plasma membrane (DMPK)
nucleus (DMPK) cytoplasm (DMPK)
Anatomy Link Frequency
skeletal muscle 3
heart 3
myoblasts 1
striatum 1
DMPK (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 14 80.64 Quite High
fibrosis 6 77.20 Quite High
Pain 12 65.24 Quite High
corticosteroid 8 64.24 Quite High
anticonvulsant 4 61.92 Quite High
Inflammation 15 59.44 Quite High
fifth nerve 1 49.36 Quite Low
Dopamine 3 48.36 Quite Low
imagery 24 5.00 Very Low Very Low Very Low
Neurotransmitter 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Frailty 62 100.00 Very High Very High Very High
Disease 150 99.92 Very High Very High Very High
Targeted Disruption 74 98.96 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 11 98.52 Very High Very High Very High
Cataract 29 98.48 Very High Very High Very High
Arrhythmias 2 Under Development 5 98.04 Very High Very High Very High
Congenital Anomalies 7 97.44 Very High Very High Very High
Myotonic Dystrophy 48 97.12 Very High Very High Very High
Hypopituitarism 96 96.92 Very High Very High Very High
Muscle Weakness 4 92.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conversely, the consequences of increased CUGBP1 stability in DM1 are demonstrated in mice transgenic for human CUGBP1 in heart and skeletal muscle that show muscle degeneration and a shift towards fetal splicing patterns of several target genes [18].
Positive_regulation (increased) of DM1 in heart associated with targeted disruption
1) Confidence 0.54 Published 2010 Journal Current Chemical Genomics Section Body Doc Link PMC2874217 Disease Relevance 0.38 Pain Relevance 0.09
DM1 is caused by expansions in CTG trinuclotide repeat tract located in the myotonic dystrophy protein kinase gene on chromosome 19q.
Positive_regulation (caused) of DM1 associated with frailty
2) Confidence 0.36 Published 2007 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699981 Disease Relevance 2.37 Pain Relevance 0.19
Conversely, the consequences of increased CUGBP1 stability in DM1 are demonstrated in mice transgenic for human CUGBP1 in heart and skeletal muscle that show muscle degeneration and a shift towards fetal splicing patterns of several target genes [18].
Positive_regulation (stability) of DM1 in heart associated with targeted disruption
3) Confidence 0.36 Published 2010 Journal Current Chemical Genomics Section Body Doc Link PMC2874217 Disease Relevance 0.38 Pain Relevance 0.09
Results from several groups support that increased activity of CUG-BP1 in DM1 is pathogenic as CUG-BP1 regulates alternative splicing of pre-mRNA transcripts antagonizing Muscleblind activity [67, 71-73].
Positive_regulation (increased) of DM1
4) Confidence 0.34 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0.24 Pain Relevance 0.04
CUG-BP1 and ETR-3 like factor (CELF) member CUG-BP1 does not bind ds(CUG) hairpins nor co-localizes with ribonuclear foci but its activity is increased in DM1 myoblasts, skeletal muscle, and heart tissues [36, 66, 67] (see [68] for a review about CELF RNA binding proteins).
Positive_regulation (increased) of DM1 in myoblasts
5) Confidence 0.30 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0.45 Pain Relevance 0.04
DM1 is caused by expansion of a CTG repeat in the 3┬┤untranslated region (UTR) of the Dystrophia Myotonica Protein Kinase (DMPK) gene.
Positive_regulation (caused) of DM1 associated with myotonic dystrophy
6) Confidence 0.28 Published 2008 Journal Current Genomics Section Abstract Doc Link PMC2694559 Disease Relevance 0.66 Pain Relevance 0
Conversely, the consequences of increased CUGBP1 stability in DM1 are demonstrated in mice transgenic for human CUGBP1 in heart and skeletal muscle that show muscle degeneration and a shift towards fetal splicing patterns of several target genes [18].
Positive_regulation (increased) of DM1 in skeletal muscle associated with targeted disruption
7) Confidence 0.18 Published 2010 Journal Current Chemical Genomics Section Body Doc Link PMC2874217 Disease Relevance 0.38 Pain Relevance 0.09
Conversely, the consequences of increased CUGBP1 stability in DM1 are demonstrated in mice transgenic for human CUGBP1 in heart and skeletal muscle that show muscle degeneration and a shift towards fetal splicing patterns of several target genes [18].
Positive_regulation (stability) of DM1 in skeletal muscle associated with targeted disruption
8) Confidence 0.12 Published 2010 Journal Current Chemical Genomics Section Body Doc Link PMC2874217 Disease Relevance 0.38 Pain Relevance 0.09
CUG-BP1 and ETR-3 like factor (CELF) member CUG-BP1 does not bind ds(CUG) hairpins nor co-localizes with ribonuclear foci but its activity is increased in DM1 myoblasts, skeletal muscle, and heart tissues [36, 66, 67] (see [68] for a review about CELF RNA binding proteins).
Positive_regulation (increased) of DM1 in heart
9) Confidence 0.10 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0.45 Pain Relevance 0.04
CUG-BP1 and ETR-3 like factor (CELF) member CUG-BP1 does not bind ds(CUG) hairpins nor co-localizes with ribonuclear foci but its activity is increased in DM1 myoblasts, skeletal muscle, and heart tissues [36, 66, 67] (see [68] for a review about CELF RNA binding proteins).
Positive_regulation (increased) of DM1 in skeletal muscle
10) Confidence 0.10 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0.45 Pain Relevance 0.04
Our results are also in agreement with similar levels of instability seen in knock-in and fragment transgenic models of HD that exhibit different rates of inclusion formation [24], and with the observation that striatal instability occurs in SCA1 and DM1, although the striatum is not the target of pathogenesis in these disorders [2,5].


Positive_regulation (occurs) of DM1 in striatum associated with targeted disruption and disease
11) Confidence 0.03 Published 2010 Journal BMC Syst Biol Section Body Doc Link PMC2856555 Disease Relevance 0.70 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox