INT272513

Context Info Confidence 0.03 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0

cell differentiation (Mef2a) nucleus (Mef2a) translation (Eif2s2) DNA binding (Mef2a)

Anatomy Link Frequency myoblasts 1 Mef2a (Mus musculus) Eif2s2 (Mus musculus)

Pain Link Frequency Relevance Heat Kinase C 2 5.00 tolerance 1 5.00 abdominal pain 1 5.00

Disease Link Frequency Relevance Heat Myotonic Dystrophy 8 50.00 Disease 13 5.00 Hypopituitarism 11 5.00 Targeted Disruption 8 5.00 Cataract 4 5.00 Frailty 3 5.00 Toxicity 2 5.00 Arrhythmia Under Development 2 5.00 Ataxia 2 5.00 Sleep Disorders 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

[93] and Mef2A [70] in differentiating cells by interacting with translation initiation factor eIF2, the mechanism by which translation was inefficient in DM1 muscle cells was not fully understood, in particular after confirming that the levels of CUG-BP1 mRNA did not show any significant change in DM1 muscle cells when compared to normal myoblasts [94].

Mef2A Binding (interacting) of eIF2 in myoblasts

1) Confidence 0.03 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.