INT272517

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.07
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Ccnd1, Celf1) nucleus (Ccnd1, Celf1) intracellular (Ccnd1)
enzyme binding (Ccnd1) mRNA binding (Celf1) RNA binding (Celf1)
Ccnd1 (Mus musculus)
Celf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
spastic colon 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 35 65.52 Quite High
Disease 39 50.00 Quite Low
Myotonic Dystrophy 38 50.00 Quite Low
Stress 1 26.88 Quite Low
Hypopituitarism 22 5.00 Very Low Very Low Very Low
Toxicity 20 5.00 Very Low Very Low Very Low
Cataract 15 5.00 Very Low Very Low Very Low
Myotonia 14 5.00 Very Low Very Low Very Low
Frailty 13 5.00 Very Low Very Low Very Low
Congenital Anomalies 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ph-Ser302-CUGBP1 strongly binds to mRNA encoding a cdk inhibitor, p21, while binding of CUGBP1 to cyclin D1 mRNA is weaker.
cyclin D1 Binding (binding) of CUGBP1
1) Confidence 0.08 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.07 Pain Relevance 0
Serine/threonine-specific protein kinase family member Akt phosphorylated CUG-BP1 at Ser28 and increased interaction of CUG-BP1 with cyclin D1 mRNA, which is a strong promoter of cell proliferation.
cyclin D1 mRNA Binding (interaction) of CUG-BP1
2) Confidence 0.01 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0 Pain Relevance 0
Serine/threonine-specific protein kinase family member Akt phosphorylated CUG-BP1 at Ser28 and increased interaction of CUG-BP1 with cyclin D1 mRNA, which is a strong promoter of cell proliferation.
cyclin D1 mRNA Binding (interaction) of CUG-BP1
3) Confidence 0.01 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0 Pain Relevance 0

General Comments

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