INT272524

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.07
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (DICER1, Dmpk) cytosol (DICER1, Dmpk) mitochondrion (Dmpk)
endoplasmic reticulum (Dmpk) intracellular (DICER1) helicase activity (DICER1)
DICER1 (Homo sapiens)
Dmpk (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 2 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myotonic Dystrophy 8 75.00 Quite High
Cataract 4 40.44 Quite Low
Arrhythmias 2 Under Development 1 40.00 Quite Low
Hypopituitarism 11 38.88 Quite Low
Frailty 3 38.48 Quite Low
Disease 13 5.00 Very Low Very Low Very Low
Targeted Disruption 8 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low
Arrhythmia Under Development 2 5.00 Very Low Very Low Very Low
Ataxia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, transcripts containing long hairpin structures of CUG repeats have been shown to be a Dicer ribonuclease target and Dicer-induced downregulation of the mutant DMPK transcripts triggers silencing effects on RNAs containing long complementary repeats.
Dicer Negative_regulation (downregulation) of DMPK
1) Confidence 0.04 Published 2008 Journal Current Genomics Section Abstract Doc Link PMC2694559 Disease Relevance 0.07 Pain Relevance 0

General Comments

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