INT272575

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Context Info
Confidence 0.36
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 7
Disease Relevance 0.54
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Cacng2) neurological system process (Cacng2)
Anatomy Link Frequency
tail 1
Cacng2 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 160 97.00 Very High Very High Very High
nMDA receptor 12 94.52 High High
conotoxin 5 79.12 Quite High
Kinase C 18 77.44 Quite High
central sensitization 9 76.88 Quite High
antagonist 45 69.12 Quite High
Spinal sensitization 1 62.64 Quite High
Glutamate receptor 120 61.20 Quite High
Hyperalgesia 4 54.40 Quite High
Inflammation 9 53.88 Quite High
Disease Link Frequency Relevance Heat
Stress 10 91.20 High High
Disease 47 85.80 High High
Nociception 26 59.04 Quite High
Aids-related Complex 2 57.84 Quite High
Hyperalgesia 5 54.40 Quite High
INFLAMMATION 9 53.88 Quite High
Schizophrenia 13 50.00 Quite Low
Intellectual Impairment 16 40.84 Quite Low
Rupture 10 34.48 Quite Low
Inflammatory Pain 9 28.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PSD-95 expression affects AMPA receptor-mediated excitatory synaptic transmission (Migaud et al, 1998; Beique et al, 2006; Carlisle et al, 2008) and is thought to involve indirect interactions through stargazin, SAP-97, Adam22, Lgi1 and Nsf (Leonard et al, 1998; Osten et al, 1998; Fukata et al, 2006).
stargazin Binding (interactions) of
1) Confidence 0.36 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2694677 Disease Relevance 0.14 Pain Relevance 0.08
This indicates that the interaction between stargazin/TARPs and AMPA-Rs is sensitive to detergents.
stargazin Binding (interaction) of
2) Confidence 0.36 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2992128 Disease Relevance 0 Pain Relevance 0.08
Functional interaction between stargazin/TARPs and AMPA-Rs can decrease in the presence of a high concentration of glutamate [98].
stargazin Binding (interaction) of associated with glutamate
3) Confidence 0.36 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2992128 Disease Relevance 0 Pain Relevance 0.17
Consistently, stargazin/TARPs form a stable complex with GluR2 tetramers but not with the dimer intermediates during biogenesis.
stargazin Binding (complex) of
4) Confidence 0.36 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2992128 Disease Relevance 0.18 Pain Relevance 0
Immunolabeling of the particles with Fab fragments that specifically recognize the C-terminus of the stargazin/TARPs consistently labeled the bottom part of the transmembrane density, indicating that the large transmembrane density contained the stargazin/TARPs.
stargazin Binding (recognize) of
5) Confidence 0.36 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2992128 Disease Relevance 0 Pain Relevance 0
The cytoplasmic C-terminus of the stargazin/TARPs is critical for modulating AMPA-R gating [99, 128], and thus any potions of the AMPA-R that are exposed to the cytoplasm are candidate interacting targets of stargazin/TARPs.
stargazin Binding (interacting) of
6) Confidence 0.35 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2992128 Disease Relevance 0 Pain Relevance 0.03
Binding of the C-terminal tail of Stargazin to PDZ domains of a number of synaptic scaffolding proteins, such as PSD-95 (an interacting protein associated with NR2 subunits of the NMDA receptors) may mediate the synaptic targeting of surface AMPA receptors [56].
Stargazin Binding (Binding) of in tail associated with nmda receptor
7) Confidence 0.13 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.22 Pain Relevance 0.24

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