INT27258

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Context Info
Confidence 0.60
First Reported 1988
Last Reported 2010
Negated 3
Speculated 3
Reported most in Abstract
Documents 18
Total Number 21
Disease Relevance 6.37
Pain Relevance 11.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Htr2a) cell death (Htr2a) aging (Htr2a)
plasma membrane (Htr2a) response to stress (Htr2a) cytoplasm (Htr2a)
Anatomy Link Frequency
spinal cord 3
brain 2
cerebral cortex 2
plasma 1
midbrain 1
Htr2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 42 100.00 Very High Very High Very High
fluoxetine 22 100.00 Very High Very High Very High
Analgesic 21 100.00 Very High Very High Very High
Serotonin 20 100.00 Very High Very High Very High
Spinal cord 17 100.00 Very High Very High Very High
tolerance 14 100.00 Very High Very High Very High
Morphine 9 100.00 Very High Very High Very High
Kappa opioid receptor 8 100.00 Very High Very High Very High
antidepressant 4 100.00 Very High Very High Very High
tricyclic antidepressant 1 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Convulsion 7 100.00 Very High Very High Very High
Body Weight 4 99.72 Very High Very High Very High
Urological Neuroanatomy 4 99.08 Very High Very High Very High
Anxiety Disorder 29 98.84 Very High Very High Very High
Hyperalgesia 17 98.68 Very High Very High Very High
Neuropathic Pain 10 97.76 Very High Very High Very High
Depression 25 97.44 Very High Very High Very High
Pain 32 96.80 Very High Very High Very High
Nociception 1 96.80 Very High Very High Very High
Injury 9 96.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Subchronic treatment with anxiolytic doses of the 5-HT1A receptor agonist ipsapirone does not affect 5-HT2 receptor sensitivity in the rat.
Neg (not) Regulation (affect) of 5-HT2 associated with anxiety disorder and agonist
1) Confidence 0.60 Published 1993 Journal Eur. J. Pharmacol. Section Title Doc Link 8095465 Disease Relevance 0.30 Pain Relevance 0.18
Ipsapirone administration for 21 days reduced fluid intake and decreased body weight, but did not affect baseline plasma glucose, corticosterone, and prolactin levels or cortical 5-HT2 receptor number.
Neg (not) Regulation (affect) of 5-HT2 in plasma associated with body weight
2) Confidence 0.60 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8095465 Disease Relevance 0.35 Pain Relevance 0.39
Comparison of the affinities of these compounds for the various 5-HT2 receptor subtypes revealed that the receptor involved in the contractions to 5-HT most closely resembles the 5-HT2A receptor.
Regulation (affinities) of 5-HT2
3) Confidence 0.44 Published 1997 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 9430791 Disease Relevance 0.10 Pain Relevance 0.22
The present study examines the influence of electroconvulsive seizure (ECS), as well as antidepressant drugs, on levels of serotonin2 (5-HT2) receptor mRNA in rat frontal cortex.
Spec (examines) Regulation (influence) of 5-HT2 in frontal cortex associated with antidepressant, convulsion and urological neuroanatomy
4) Confidence 0.44 Published 1993 Journal J. Neurochem. Section Abstract Doc Link 8376984 Disease Relevance 0.66 Pain Relevance 0.16
The present study examined the effect of a selective 5-HT2A receptor antagonist, sarpogrelate, on hyperalgesia and allodynia induced by thermal injury in rats.
Spec (examined) Regulation (effect) of 5-HT2A associated with hyperalgesia, allodynia, antagonist and injury
5) Confidence 0.44 Published 2006 Journal Pain Section Abstract Doc Link 16527395 Disease Relevance 1.46 Pain Relevance 1.08
The results suggest that 5-HT1A and the 5-HT2A receptors are involved in the regulation of acetylcholine release in the spinal cord.
Regulation (involved) of 5-HT2 in spinal cord associated with spinal cord
6) Confidence 0.44 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15733547 Disease Relevance 0 Pain Relevance 0.30
Effect of prenatal exposure to antidepressants on 5-HT-stimulated phosphoinositide hydrolysis and 5-HT2 receptors in rat brain.
Regulation (Effect) of 5-HT2 in brain associated with antidepressant
7) Confidence 0.44 Published 1994 Journal Gen. Pharmacol. Section Title Doc Link 7835628 Disease Relevance 0 Pain Relevance 0.35
The effect of repeated administration of U-50,488H, a kappa-opioid receptor agonist, on the development of tolerance to its analgesic effect and on the 5-HT1 and 5-HT2 receptors in the cerebral cortex and spinal cord of the rat were determined.
Regulation (effect) of 5-HT2 in cerebral cortex associated with analgesic, tolerance, agonist, kappa opioid receptor, cerebral cortex and spinal cord
8) Confidence 0.44 Published 1989 Journal Pharmacology Section Abstract Doc Link 2587620 Disease Relevance 0 Pain Relevance 0.65
These studies examined the effects of a 21-day treatment regime with either the tricyclic antidepressant, desmethylimipramine (DMI), or the selective 5-HT uptake inhibitor, fluoxetine, on 5-HT2 receptors in rat brain, as assessed by selective agonist-mediated c-fos gene expression.
Spec (examined) Regulation (effects) of 5-HT2 in brain associated with agonist, tricyclic antidepressant and fluoxetine
9) Confidence 0.44 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7589222 Disease Relevance 0.07 Pain Relevance 0.44
Effect of repeated administration of U-50,488H, a kappa opioid receptor agonist, on central 5-HT1 and 5-HT2 receptors in the rat.
Regulation (Effect) of 5-HT2 associated with analgesic, agonist and kappa opioid receptor
10) Confidence 0.44 Published 1989 Journal Pharmacology Section Title Doc Link 2587620 Disease Relevance 0 Pain Relevance 0.96
Methysergide may act as a neutral antagonist that blocks the effect of inverse agonists on the 5-HT 2A receptor.
Regulation (effect) of 5-HT 2A associated with antagonist and agonist
11) Confidence 0.26 Published 2005 Journal Neurochem. Int. Section Abstract Doc Link 16051396 Disease Relevance 0.85 Pain Relevance 0.83
Repeated administration of U-50,488H to rats did not affect spinal cord 5-HT1 and 5-HT2 receptors.
Neg (not) Regulation (affect) of 5-HT2 in spinal cord associated with spinal cord
12) Confidence 0.26 Published 1989 Journal Pharmacology Section Abstract Doc Link 2587620 Disease Relevance 0 Pain Relevance 0.64
At PD28, neither 5-HT2A/2C receptor density nor 5-HT2A/2C receptor-mediated endocrine responses were altered by prenatal exposure to fluoxetine.
Regulation (altered) of 5-HT2A associated with fluoxetine
13) Confidence 0.26 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8182530 Disease Relevance 0.08 Pain Relevance 0.74
The results suggest different participation of 5-HT1A-, 5-HT2- and 5-HT3-receptors in the mechanisms of memory process and its modulation by the serotonin level in the cerebral serotonergic synapses.
Regulation (participation) of 5-HT2 in synapses associated with serotonin
14) Confidence 0.26 Published 1994 Journal Acta Physiol Pharmacol Bulg Section Abstract Doc Link 7645408 Disease Relevance 0 Pain Relevance 0.70
In this study, we tested the influence of repeated treatment with the 5-HT1A receptor agonist ipsapirone (0.5 g/l in drinking water for 21 days) on some 5-HT2 receptor-mediated responses elicited by the acute injection of the 5-HT1C/5-HT2 receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI).
Regulation (responses) of 5-HT2 associated with agonist
15) Confidence 0.26 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8095465 Disease Relevance 0.28 Pain Relevance 0.14
Subchronic treatment with anxiolytic doses of the 5-HT1A receptor agonist ipsapirone does not affect 5-HT2 receptor sensitivity in the rat.
Regulation (sensitivity) of 5-HT2 associated with anxiety disorder and agonist
16) Confidence 0.26 Published 1993 Journal Eur. J. Pharmacol. Section Title Doc Link 8095465 Disease Relevance 0.30 Pain Relevance 0.21
The effect of chronic administration of morphine to rats on 5-HT1 and 5-HT2 receptors in the cerebral cortex was determined.
Regulation (effect) of 5-HT2 in cerebral cortex associated with cerebral cortex and morphine
17) Confidence 0.19 Published 1988 Journal Neuropharmacology Section Abstract Doc Link 3244405 Disease Relevance 0.12 Pain Relevance 0.79
Here we have studied the effect of various 5-HT1A and 5-HT2 receptor-selective drugs on noradrenaline release in the hippocampus on anaesthetized and awake rats using microdialysis.
Regulation (effect) of 5-HT2 in hippocampus associated with noradrenaline and hippocampus
18) Confidence 0.19 Published 1994 Journal Neuropharmacology Section Abstract Doc Link 7984279 Disease Relevance 0 Pain Relevance 0.31
Stepwise regression identified two effects in HTR2A and a single effect in TPH2 which were independent of anxiety, depression, and pain.
Regulation (effects) of HTR2A associated with pain, depression and anxiety disorder
19) Confidence 0.17 Published 2010 Journal Journal of Psychosomatic Research Section Abstract Doc Link PMC2877873 Disease Relevance 0.98 Pain Relevance 0.50
The effect of repeated administration of U-50,488H, a kappa-opioid receptor agonist, on the development of tolerance to its analgesic effect and on the 5-HT1 and 5-HT2 receptors in the cerebral cortex and spinal cord of the rat were determined.
Regulation (effect) of 5-HT2 in spinal cord associated with analgesic, tolerance, agonist, kappa opioid receptor, cerebral cortex and spinal cord
20) Confidence 0.15 Published 1989 Journal Pharmacology Section Abstract Doc Link 2587620 Disease Relevance 0 Pain Relevance 0.65

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