INT272581

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Context Info
Confidence 0.36
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.29
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gria3) plasma membrane (Gria3) protein complex (Gria3)
Anatomy Link Frequency
neuronal 1
Gria3 (Mus musculus)
Pain Link Frequency Relevance Heat
IPN 9 86.44 High High
Neuropathic pain 4 71.76 Quite High
central sensitization 9 64.32 Quite High
Spinal cord 10 62.00 Quite High
Glutamate receptor 20 56.92 Quite High
Action potential 2 54.56 Quite High
nMDA receptor 7 45.52 Quite Low
Spinal sensitization 1 26.52 Quite Low
Kinase C 18 5.00 Very Low Very Low Very Low
Pain 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Inflammatory Pain 9 86.44 High High
Hyperalgesia 5 73.84 Quite High
Neuropathic Pain 4 71.76 Quite High
Schizophrenia 13 50.00 Quite Low
Nociception 26 5.00 Very Low Very Low Very Low
Disease 12 5.00 Very Low Very Low Very Low
INFLAMMATION 9 5.00 Very Low Very Low Very Low
Pain 9 5.00 Very Low Very Low Very Low
Targeted Disruption 7 5.00 Very Low Very Low Very Low
Depression 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of the 39 MCC proteins (excluding PSD-95), 26 (67%) were primary interactors (blue symbols in Figure 5A) and 12 (31%) were secondary interactors (yellow symbols in Figure 5A) and only one protein, the AMPA receptor subunit Gria3, was a tertiary interactor.
Gria3 Binding (interactor) of
1) Confidence 0.36 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2694677 Disease Relevance 0 Pain Relevance 0.06
The role of Non-PDZ domain-containing protein, such as N-ethylmaleimide sensitive fusion (NSF) protein (an ATPase), in neuronal membrane fusion processes and regulatory interaction with GluR2 and GluR3 subunits of AMPA receptors has been investigated.
GluR3 Binding (interaction) of in neuronal
2) Confidence 0.13 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.29 Pain Relevance 0.28

General Comments

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