INT27260

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Context Info
Confidence 0.75
First Reported 1989
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 7.72
Pain Relevance 2.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DYNLL1) transport (DYNLL1) mitochondrion (DYNLL1)
plasma membrane (DYNLL1) cytoskeleton (DYNLL1) nucleus (DYNLL1)
Anatomy Link Frequency
nodes 3
PPC 1
epithelium 1
fulcrum 1
DYNLL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 10 99.72 Very High Very High Very High
Pin-prick hyperalgesia 3 99.26 Very High Very High Very High
COX-2 inhibitor 20 96.52 Very High Very High Very High
Quantitative sensory testing 4 93.44 High High
magnetoencephalography 3 89.96 High High
Lasting pain 1 86.92 High High
Hyperalgesia 10 83.88 Quite High
Pain threshold 2 81.76 Quite High
Inflammation 4 78.40 Quite High
allodynia 2 78.08 Quite High
Disease Link Frequency Relevance Heat
Reprotox - General 1 108 100.00 Very High Very High Very High
Prostatic Intraepithelial Neoplasia 28 100.00 Very High Very High Very High
Benign Prostatic Hypertrophy 28 99.90 Very High Very High Very High
Pain 8 99.72 Very High Very High Very High
Toothache 10 99.70 Very High Very High Very High
Congenital Anomalies 4 99.58 Very High Very High Very High
Hyperalgesia 14 99.26 Very High Very High Very High
Nociception 3 91.36 High High
Dislocations 1 85.36 High High
Communicable Diseases 1 83.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, the authors explain their therapeutic procedure: three times orthopaedic treatment with traction and spica cast for 2 months, a pin osteosynthesis in one case.
Gene_expression (osteosynthesis) of pin
1) Confidence 0.75 Published 1989 Journal Z Kinderchir Section Abstract Doc Link 2588805 Disease Relevance 0.62 Pain Relevance 0.17
A certain risk associated with Dynesys use may lie in disc height reduction in the anterior segment by up to 0.7 mm, thus producing a fulcrum pin effect.
Gene_expression (producing) of pin in fulcrum
2) Confidence 0.75 Published 2010 Journal Acta Chir Orthop Traumatol Cech Section Body Doc Link 20619111 Disease Relevance 0 Pain Relevance 0
The most common qualitative abnormalities in AO patients were found with pin-prick 67.4%, cold 47.8%, and touch 46.5% compared with 11.4%, 8.6%, and 2.9%, respectively, in the control group (P<0.001).
Gene_expression (found) of pin associated with toothache and congenital anomalies
3) Confidence 0.65 Published 2008 Journal Pain Section Abstract Doc Link 18571324 Disease Relevance 1.46 Pain Relevance 0.82
During pin-prick hyperalgesia significantly higher activation was detected in contralateral PPC and bilateral S2 but not in S1 compared to normal pin-prick pain.
Neg (not) Gene_expression (detected) of pin in PPC associated with pain, hyperalgesia and pin-prick hyperalgesia
4) Confidence 0.65 Published 2010 Journal Eur J Pain Section Abstract Doc Link 19346142 Disease Relevance 1.24 Pain Relevance 1.40
METHODS: In 10 healthy subjects the blink reflex was elicited using a standard (10-15 mA) and a new concentric surface electrode type (0.6-1.6 mA) which produces a pin-prick-like pain.
Gene_expression (produces) of pin
5) Confidence 0.58 Published 2000 Journal Clin Neurophysiol Section Body Doc Link 10699400 Disease Relevance 0.09 Pain Relevance 0
However, only in epithelium of PC tissues, COX-2 expression was more intensive and extensive than that in NP, BPH and PIN tissues, and COX-2 expression was stronger in low differentiation PC (Yoshimura et al 2000).
Gene_expression (tissues) of PIN in epithelium associated with prostatic intraepithelial neoplasia, benign prostatic hypertrophy and reprotox - general 1
6) Confidence 0.11 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727910 Disease Relevance 2.38 Pain Relevance 0.09
We have shown that 5- and 12-LOX expressions in PC and PIN tissue are stronger than those in NP and BPH tissues by immunohistochemical staining (174 PC, 20 PIN, 20 BPH, and 20 NP tissues) and RT-PCR.
Gene_expression (expressions) of PIN associated with benign prostatic hypertrophy, prostatic intraepithelial neoplasia and reprotox - general 1
7) Confidence 0.11 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727910 Disease Relevance 1.93 Pain Relevance 0.31
The BPI conducted by PINT relies on putatively identical nodes (PIN) sets (see section ‘The pathways integration rule’), but not on any gene or protein expression data.
Gene_expression (expression) of PIN in nodes
8) Confidence 0.10 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2896112 Disease Relevance 0 Pain Relevance 0
Thus, nodes N1 and N2 as a whole is a putatively identical node (PIN) set; nodes N3 and N4 as a whole is another PIN set.
Gene_expression (set) of PIN in PIN
9) Confidence 0.10 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2896112 Disease Relevance 0 Pain Relevance 0
The BPI conducted by PINT relies on putatively identical nodes (PIN) sets (see section ‘The pathways integration rule’), but not on any gene or protein expression data.
Neg (not) Gene_expression (relies) of PIN in nodes
10) Confidence 0.10 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2896112 Disease Relevance 0 Pain Relevance 0

General Comments

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