INT272602

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Context Info
Confidence 0.09
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.19
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Dlg4, Gria2) transport (Gria2) endoplasmic reticulum (Gria2)
structural molecule activity (Dlg4) protein complex assembly (Dlg4) protein complex (Gria2)
Anatomy Link Frequency
spinal 1
Dlg4 (Mus musculus)
Gria2 (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 10 100.00 Very High Very High Very High
Spinal sensitization 1 98.76 Very High Very High Very High
central sensitization 9 96.60 Very High Very High Very High
Glutamate receptor 29 74.68 Quite High
Kinase C 18 59.92 Quite High
Hyperalgesia 4 36.88 Quite Low
Inflammation 9 36.36 Quite Low
spinal dorsal horn 7 29.24 Quite Low
IPN 9 11.44 Low Low
Pain 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 23 99.28 Very High Very High Very High
Schizophrenia 26 50.00 Quite Low
Nociception 26 41.52 Quite Low
Aids-related Complex 4 40.16 Quite Low
Hyperalgesia 5 36.88 Quite Low
INFLAMMATION 9 36.36 Quite Low
Inflammatory Pain 9 11.44 Low Low
Targeted Disruption 13 5.00 Very Low Very Low Very Low
Pain 10 5.00 Very Low Very Low Very Low
Neuropathic Pain 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, it may suggest that the Stargazin-mediated interaction of AMPA receptors with PSD-95 is possibly implicated in the spinal sensitization.
PSD-95 Binding (interaction) of AMPA in spinal associated with spinal sensitization
1) Confidence 0.09 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0 Pain Relevance 0.17
Although PSD-95 is a known direct binding partner of NMDA receptors, there is conflicting data about physical interactions between PSD-95 and AMPA receptor subunits.
PSD-95 Binding (interactions) of AMPA receptor associated with nmda receptor
2) Confidence 0.02 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2694677 Disease Relevance 0.10 Pain Relevance 0.08
Although PSD-95 is a known direct binding partner of NMDA receptors, there is conflicting data about physical interactions between PSD-95 and AMPA receptor subunits.
PSD-95 Binding (interactions) of AMPA receptor associated with nmda receptor
3) Confidence 0.02 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2694677 Disease Relevance 0.10 Pain Relevance 0.09

General Comments

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