INT272603

Context Info Confidence 0.23 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.03

plasma membrane (Dlg4, Nlgn2) cell adhesion (Nlgn2) structural molecule activity (Dlg4) protein complex assembly (Dlg4) cytoplasm (Dlg4)

Dlg4 (Mus musculus) Nlgn2 (Mus musculus)

Pain Link Frequency Relevance Heat Glutamate receptor 9 65.36 nMDA receptor 3 9.68 Neurotransmitter 4 5.00 long-term potentiation 3 5.00 Glutamate 3 5.00 Action potential 2 5.00 Pain 1 5.00 potassium channel 1 5.00 addiction 1 5.00 Hippocampus 1 5.00

Disease Link Frequency Relevance Heat Schizophrenia 13 50.00 Disease 11 15.20 Targeted Disruption 6 5.00 Aids-related Complex 2 5.00 Pain 1 5.00 Congenital Anomalies 1 5.00 Adhesions 1 5.00 Cognitive Disorder 1 5.00 Intellectual Impairment 1 5.00 Manic Depressive Disorder 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Also, we observed that the two-step procedure unmasked core interacting proteins that were not detected by mass spectrometry in the single-step purification: Ten known PSD-95 interactors, Begain, Cit, Grik2, Grik5, Grin2c, Kcna4, Lrp1, Nlgn2, Nlgn3 and Shank1, were present only after the tandem purification.

PSD-95 Binding (interactors) of Nlgn2

1) Confidence 0.23 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2694677 Disease Relevance 0 Pain Relevance 0.03

General Comments

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