INT27266

Context Info Confidence 0.62 First Reported 1985 Last Reported 2010 Negated 9 Speculated 7 Reported most in Abstract Documents 41 Total Number 47 Disease Relevance 6.74 Pain Relevance 14.59

signal transduction (Pomc) generation of precursor metabolites and energy (Pomc) extracellular space (Pomc) extracellular region (Pomc) cell-cell signaling (Pomc) cytoplasm (Pomc)

Anatomy Link Frequency pituitary 8 plasma 7 brain 6 anterior pituitary 6 PVN 4 Pomc (Mus musculus)

Pain Link Frequency Relevance Heat Morphine 89 100.00 Central nervous system 64 100.00 Somatostatin 44 100.00 Neuropeptide 28 100.00 Enkephalin 24 100.00 narcan 15 100.00 Dismenorea 4 100.00 transcutaneous nerve stimulation 4 100.00 dexamethasone 26 99.98 Perioperative pain 4 99.80

Disease Link Frequency Relevance Heat Appetite Loss 44 100.00 Acth-secreting Pituitary Adenoma 7 100.00 Post Operative Pain 4 99.80 Poisoning 3 99.50 Embryonal Carcinoma 1 99.40 Endometriosis (extended) 3 98.48 Pain 5 98.44 Pituitary Cancer 11 98.00 Targeted Disruption 96 97.60 Adenoma 5 97.08

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Studies focused on changes in POMC gene expression (mRNA quantitation) and post-translational processing.

Regulation (changes) of Gene_expression (expression) of POMC gene

1) Confidence 0.62 Published 1988 Journal Alcohol Section Abstract Doc Link 2969250 Disease Relevance 0.16 Pain Relevance 0.32

In that, GABAergic neurotransmission appear to be involved in the regulation of the hypothalamic POMC gene expression induced by supraspinal morphine administration.

Regulation (regulation) of Gene_expression (expression) of POMC gene associated with gabaergic and morphine

2) Confidence 0.62 Published 2009 Journal Brain Res. Bull. Section Abstract Doc Link 19723567 Disease Relevance 0 Pain Relevance 0.77

POMC gene expression in the CNS is believed to be controlled by distinct cis-acting regulatory sequences.

Regulation (controlled) of Gene_expression (expression) of POMC gene

3) Confidence 0.62 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9712635 Disease Relevance 0.16 Pain Relevance 0.10

Therefore, the influence of the TIQ salsolinol (SAL) on the pro-opiomelanocortin (POMC) gene expression was investigated using the ArT-20 mouse anterior pituitary tumor cell line.

Regulation (influence) of Gene_expression (expression) of pro-opiomelanocortin in anterior pituitary associated with pituitary cancer

4) Confidence 0.62 Published 1995 Journal Alcohol Section Abstract Doc Link 8519440 Disease Relevance 0.19 Pain Relevance 0.29

In addition, the proopiomelanocortin (POMC) gene expression was significantly down regulated in serum-reduced medium and was normalized again after further cultivation in a 10% serum containing medium.

Regulation (regulated) of Gene_expression (expression) of POMC

5) Confidence 0.60 Published 1994 Journal Cell. Mol. Biol. (Noisy-le-grand) Section Abstract Doc Link 8003951 Disease Relevance 0 Pain Relevance 0.08

However, i.t. glutamate injection did not affect the hypothalamic POMC gene expression at all time points.

Neg (not) Regulation (affect) of Gene_expression (expression) of POMC gene associated with glutamate

6) Confidence 0.59 Published 2008 Journal Neuroscience Section Abstract Doc Link 18329177 Disease Relevance 0.16 Pain Relevance 0.22

Similarly, morphine had no effect on ACTH production by dispersed rat pituitary cells in monolayer culture in response to 90- and 180-min incubations with 5 nM CRH.

Neg (no) Regulation (effect) of Gene_expression (production) of ACTH in pituitary associated with morphine

7) Confidence 0.57 Published 1985 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2984235 Disease Relevance 0 Pain Relevance 1.04

We studied the effects of supraspinally administered morphine on the expression of the hypothalamic pro-opiomelanocortin (POMC) gene and beta-endorphin.

Regulation (effects) of Gene_expression (expression) of hypothalamic pro-opiomelanocortin associated with morphine

8) Confidence 0.54 Published 2009 Journal Brain Res. Bull. Section Abstract Doc Link 19723567 Disease Relevance 0 Pain Relevance 0.47

Possible involvement of the hypothalamic pro-opiomelanocortin gene and beta-endorphin expression on acute morphine withdrawal development.

Spec (Possible) Regulation (involvement) of Gene_expression (expression) of beta-endorphin associated with withdrawal and morphine

9) Confidence 0.45 Published 2009 Journal Brain Res. Bull. Section Title Doc Link 19723567 Disease Relevance 0 Pain Relevance 0.57

We studied the effects of supraspinally administered morphine on the expression of the hypothalamic pro-opiomelanocortin (POMC) gene and beta-endorphin.

Regulation (effects) of Gene_expression (expression) of beta-endorphin associated with morphine

10) Confidence 0.45 Published 2009 Journal Brain Res. Bull. Section Abstract Doc Link 19723567 Disease Relevance 0 Pain Relevance 0.48

The existing information indicating the importance of beta-endorphin neurotransmission in mediating the reward pathways of nicotine and THC, is thus far circumstantial.

Regulation (importance) of Gene_expression (neurotransmission) of beta-endorphin associated with nicotine

11) Confidence 0.45 Published 2008 Journal Prog. Neurobiol. Section Abstract Doc Link 18602444 Disease Relevance 0 Pain Relevance 0.31

Effect of S(-)- and R(+)-salsolinol on the POMC gene expression and ACTH release of an anterior pituitary cell line.

Regulation (Effect) of Gene_expression (expression) of POMC gene in anterior pituitary

12) Confidence 0.45 Published 1995 Journal Alcohol Section Title Doc Link 8519440 Disease Relevance 0.17 Pain Relevance 0.33

The role of POMC-derived peptides of pituitary origin in the modulation of brain POMC mRNA expression and opioid receptor binding was investigated using a line of transgenic mice that express a fusion gene composed of the pituitary expression-specific promoter region of the POMC gene driving the herpes simplex viral-1 thymidine kinase (TK).

Regulation (modulation) of Gene_expression (expression) of POMC mRNA in pituitary associated with targeted disruption, herpes simplex virus and opioid receptor

13) Confidence 0.45 Published 2001 Journal J. Neuroendocrinol. Section Abstract Doc Link 11578531 Disease Relevance 0.36 Pain Relevance 0.22

We studied the effects of supraspinally administered morphine on the expression of the hypothalamic pro-opiomelanocortin (POMC) gene and beta-endorphin.

Regulation (effects) of Gene_expression (expression) of POMC associated with morphine

14) Confidence 0.44 Published 2009 Journal Brain Res. Bull. Section Abstract Doc Link 19723567 Disease Relevance 0 Pain Relevance 0.47

Therefore, the influence of the TIQ salsolinol (SAL) on the pro-opiomelanocortin (POMC) gene expression was investigated using the ArT-20 mouse anterior pituitary tumor cell line.

Regulation (influence) of Gene_expression (expression) of POMC in anterior pituitary associated with pituitary cancer

15) Confidence 0.44 Published 1995 Journal Alcohol Section Abstract Doc Link 8519440 Disease Relevance 0.19 Pain Relevance 0.29

In addition, the proopiomelanocortin (POMC) gene expression was significantly down regulated in serum-reduced medium and was normalized again after further cultivation in a 10% serum containing medium.

Regulation (regulated) of Gene_expression (expression) of POMC

16) Confidence 0.44 Published 1994 Journal Cell. Mol. Biol. (Noisy-le-grand) Section Abstract Doc Link 8003951 Disease Relevance 0 Pain Relevance 0.08

Results indicate that the ACTH levels and IFN-alpha gene expression were higher in the conditioned animals than in the controls.

Regulation (higher) of Gene_expression (expression) of ACTH

17) Confidence 0.42 Published 1994 Journal Neuroimmunomodulation Section Abstract Doc Link 8528888 Disease Relevance 0 Pain Relevance 0.15

This implies that hypothalamic TRH release is controlled by POMC and AgRP neurones.

Regulation (controlled) of Gene_expression (neurones) of POMC

18) Confidence 0.41 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.21 Pain Relevance 0.08

Neuroendocrine targets for POMC products in the PVN

Regulation (targets) of Gene_expression (products) of POMC

19) Confidence 0.41 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.16 Pain Relevance 0.07

Hypothalamic expression levels of peptides known to be involved in appetite regulation, such as NPY, POMC, and AGRP, are changed upon food deprivation, and neurons expressing these molecules are essential components in the control of energy homeostasis [8].

Regulation (changed) of Gene_expression (expression) of POMC in neurons associated with appetite loss

20) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827556 Disease Relevance 1.42 Pain Relevance 0

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