INT27267

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Context Info
Confidence 0.80
First Reported 1983
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 1.76
Pain Relevance 2.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Trh) plasma membrane (Trh) nucleus (Trh)
cytoplasm (Trh)
Anatomy Link Frequency
brain 2
cleavage 1
endocrine glands 1
PVN 1
Trh (Mus musculus)
Pain Link Frequency Relevance Heat
Cholecystokinin 9 100.00 Very High Very High Very High
Enkephalin 6 100.00 Very High Very High Very High
noradrenaline 3 100.00 Very High Very High Very High
Clonidine 3 97.48 Very High Very High Very High
agonist 12 96.48 Very High Very High Very High
Somatostatin 10 96.20 Very High Very High Very High
narcan 8 92.96 High High
Morphine 8 92.80 High High
Neuropeptide 4 91.16 High High
Central nervous system 19 90.28 High High
Disease Link Frequency Relevance Heat
Marinesco Sjogren Syndrome 4 97.84 Very High Very High Very High
Parkinson's Disease 6 97.56 Very High Very High Very High
Fibromyalgia 10 97.54 Very High Very High Very High
Sleep Disorders 1 95.12 Very High Very High Very High
Psychosis 1 86.24 High High
Dyskinesias 1 84.24 Quite High
Stress 6 79.92 Quite High
Ataxia 2 75.00 Quite High
Disease 2 75.00 Quite High
Body Weight 3 60.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The release of the TRH analogue in the brain is orchestrated by a sequential metabolism utilizing esterase/lipase, peptidyl glycine alpha-amidating monooxygenase (PAM), peptidase cleavage, and glutaminyl cyclase.
Localization (release) of TRH in cleavage
1) Confidence 0.80 Published 1999 Journal J. Med. Chem. Section Abstract Doc Link 10579819 Disease Relevance 0 Pain Relevance 0.11
Evidence for a peripheral action of thyrotropin releasing hormone on gastrointestinal transit in mice.
Localization (releasing) of thyrotropin releasing hormone
2) Confidence 0.75 Published 1988 Journal Neuropharmacology Section Title Doc Link 2901674 Disease Relevance 0 Pain Relevance 0.44
These studies revealed the pattern of central distribution of specific TRH binding sites.
Localization (distribution) of TRH
3) Confidence 0.75 Published 1983 Journal Peptides Section Abstract Doc Link 6312436 Disease Relevance 0 Pain Relevance 0.18
Studies on the mechanism of thyrotropin releasing hormone induced inhibition of gastrointestinal transit.
Localization (releasing) of thyrotropin releasing hormone
4) Confidence 0.75 Published 1985 Journal Peptides Section Title Doc Link 3929234 Disease Relevance 0 Pain Relevance 0.26
Behavioural and biochemical evidence for the release of noradrenaline in mouse brain by TRH and some of its biologically stable analogues.
Localization (release) of TRH in brain associated with noradrenaline
5) Confidence 0.71 Published 1987 Journal Neuropharmacology Section Title Doc Link 2884590 Disease Relevance 0.10 Pain Relevance 0.33
The clinical efficacy, dose-response relationship, and safety of TRH-T (thyrotropin releasing hormone tartrate) were assessed in 290 patients with spinocerebellar degeneration (SCD) in a 2-week, double-blind study using placebo as control. 254 patients satisfied the criteria for inclusion in evaluation of the drug efficacy.
Localization (releasing) of TRH associated with marinesco sjogren syndrome
6) Confidence 0.34 Published 1983 Journal J. Neurol. Sci. Section Abstract Doc Link 6417282 Disease Relevance 0.40 Pain Relevance 0
Using immunohistochemistry, coronal sections trough the entire PVN were double-stained with a mouse monoclonal antibody against GR and one of the following antisera: rabbit antiserum to corticotropin releasing factor (CRF), neurotensin (NT), enkephalin (ENK), cholecystokinin (CCK), thyrotropin releasing hormone (TRH), galanin (GAL), peptide histidine isoleucine (PHI), vasoactive intestinal polypeptide (VIP), somatostatin (SOM) or tyrosine hydroxylase (TH).
Localization (releasing) of TRH in PVN associated with somatostatin, enkephalin and cholecystokinin
7) Confidence 0.27 Published 1989 Journal Exp Brain Res Section Abstract Doc Link 2591516 Disease Relevance 0 Pain Relevance 0.40
In agreement with post-mortem brain studies, increased responses of prolactin secretion to TRH in vivo also suggested a decreased D-2 receptor function in parkinsonian patients with recent onset and supersensitivity in patients with on-off phenomena.
Localization (secretion) of TRH in brain associated with parkinson's disease
8) Confidence 0.26 Published 1983 Journal J. Neural Transm. Suppl. Section Abstract Doc Link 6308149 Disease Relevance 0.58 Pain Relevance 0.25
This implies that hypothalamic TRH release is controlled by POMC and AgRP neurones.
Localization (release) of TRH
9) Confidence 0.20 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.20 Pain Relevance 0.08
To study the hormonal perturbations in FMS patients we injected sixteen FMS patients and seventeen controls a cocktail of the hypothalamic releasing hormones: Corticotropin-releasing hormone (CRH), Thyrotropin-releasing hormone (TRH), Growth hormone-releasing hormone (GHRH), and Luteinizing hormone-releasing hormone (LHRH) and observed the hormonal secretion pattern of the pituitary together with the hormones of the peripheral endocrine glands.
Localization (secretion) of Thyrotropin-releasing hormone in endocrine glands associated with fibromyalgia
10) Confidence 0.13 Published 1998 Journal Z Rheumatol Section Abstract Doc Link 10025090 Disease Relevance 0.48 Pain Relevance 0.04
Apomorphine, however, completely abolished both the suckling- and TRH-induced release of prolactin.
Localization (release) of TRH
11) Confidence 0.06 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3097561 Disease Relevance 0 Pain Relevance 0.40

General Comments

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