INT27268

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Context Info
Confidence 0.21
First Reported 1984
Last Reported 2011
Negated 4
Speculated 2
Reported most in Body
Documents 71
Total Number 73
Disease Relevance 56.93
Pain Relevance 12.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Gtf3a) nucleus (Gtf3a) intracellular (Gtf3a)
DNA binding (Gtf3a)
Anatomy Link Frequency
macrophages 4
neuron 4
nucleus 3
endothelial cells 3
dorsal horn 2
Gtf3a (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 462 100.00 Very High Very High Very High
rheumatoid arthritis 411 100.00 Very High Very High Very High
Nerve growth factor 8 100.00 Very High Very High Very High
Inflammation 737 99.98 Very High Very High Very High
neurotrophin 3 1 99.80 Very High Very High Very High
Glutamate 126 99.20 Very High Very High Very High
agonist 72 99.20 Very High Very High Very High
Central nervous system 127 99.08 Very High Very High Very High
metalloproteinase 25 99.06 Very High Very High Very High
Nicotine 13 98.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 832 100.00 Very High Very High Very High
Rheumatoid Arthritis 419 100.00 Very High Very High Very High
Necrosis 75 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 18 100.00 Very High Very High Very High
Leukemia 9 100.00 Very High Very High Very High
INFLAMMATION 838 99.98 Very High Very High Very High
Renal Cancer 18 99.84 Very High Very High Very High
Apoptosis 667 99.78 Very High Very High Very High
Recurrence 79 99.60 Very High Very High Very High
Skin Cancer 10 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A platelet activating factor antagonist and a matrix metalloproteinase inhibitor, which also inhibits tumor necrosis factor alpha release, were administered to animals at the time of the MDM inoculation.
Localization (release) of factor in MDM associated with necrosis, cancer, antagonist and metalloproteinase
1) Confidence 0.21 Published 2001 Journal J. Neuroimmunol. Section Abstract Doc Link 11240016 Disease Relevance 1.05 Pain Relevance 0.31
Several recent studies on corticotropin-releasing factor (CRF) have suggested that this neuropeptide may play a role in depression.
Localization (releasing) of factor associated with depression and neuropeptide
2) Confidence 0.13 Published 2003 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 12787849 Disease Relevance 0.55 Pain Relevance 0.40
We conclude that cAMP-elevating drugs shift the balance of T cell-derived cytokines from a proinflammatory to an enhanced anti-inflammatory factor release, thus protecting mice from TNF-mediated hepatic failure.
Localization (release) of factor in T cell associated with liver failure, inflammation and cytokine
3) Confidence 0.08 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8996181 Disease Relevance 0.68 Pain Relevance 0.26
Upon stimulation of secretion by corticotropin-releasing factor, a beta-adrenergic agonist, or barium ions, secretion of PAM activity, enkephalin convertase activity, and immunoactive hormone rose in parallel.
Localization (secretion) of factor associated with agonist and enkephalin
4) Confidence 0.07 Published 1984 Journal Endocrinology Section Abstract Doc Link 6092033 Disease Relevance 0.17 Pain Relevance 0.38
Interleukin (IL)-10, a potent anti-inflammatory cytokine, limits the severity of acute pancreatitis and downregulates transforming growth factor (TGF)-beta release by inflammatory cells on stimulation.
Localization (release) of factor associated with inflammation, pancreatitis and cytokine
5) Confidence 0.06 Published 2002 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 12016137 Disease Relevance 0.80 Pain Relevance 0.30
Macrophage inflammatory protein-1 delta: a novel osteoclast stimulating factor secreted by renal cell carcinoma bone metastasis.
Localization (secreted) of factor in Macrophage associated with inflammation, renal cancer and metastasis
6) Confidence 0.06 Published 2008 Journal Cancer Res. Section Title Doc Link 18316587 Disease Relevance 1.74 Pain Relevance 0.22
Here, we report the discovery of a novel osteoclast stimulatory factor secreted by RCC bone metastasis (RBM).
Localization (secreted) of factor in osteoclast associated with renal cancer and metastasis
7) Confidence 0.06 Published 2008 Journal Cancer Res. Section Abstract Doc Link 18316587 Disease Relevance 1.74 Pain Relevance 0.22
Association between the TNFRII 196R allele and diagnosis of rheumatoid arthritis

Tumour necrosis factor (TNF)-?

Localization (allele) of factor associated with necrosis, cancer and rheumatoid arthritis
8) Confidence 0.05 Published 2005 Journal Arthritis Res Ther Section Title Doc Link PMC1257430 Disease Relevance 1.08 Pain Relevance 0.36
First, multiple growth factors or transplant cells that secrete the desired factor can be delivered.
Localization (secrete) of factor
9) Confidence 0.04 Published 2009 Journal Pharm Res Section Body Doc Link PMC2812420 Disease Relevance 0.46 Pain Relevance 0
The combination of the different molecular weight polymers, both oxidized, allows us to create gels that degrade in vitro and in vivo in an appropriate time for drug delivery, while maintaining the ability of the system to form space filling gels that can provide a sustained release of a protein growth factor.
Localization (release) of factor
10) Confidence 0.04 Published 2009 Journal Pharm Res Section Body Doc Link PMC2812420 Disease Relevance 0.32 Pain Relevance 0
Finally, the release profile of the growth factor from the system should be controlled temporally and spatially to be appropriate for a specific tissue injury or disease.
Localization (release) of factor associated with injury and disease
11) Confidence 0.04 Published 2009 Journal Pharm Res Section Body Doc Link PMC2812420 Disease Relevance 0.31 Pain Relevance 0
Neutrophils and macrophages are important inflammatory cells and the secretion of tumour necrosis factor-?
Localization (secretion) of factor in Neutrophils associated with necrosis, inflammation and cancer
12) Confidence 0.04 Published 2006 Journal Arthritis Res Ther Section Abstract Doc Link PMC1794524 Disease Relevance 1.29 Pain Relevance 0.46
It may be noteworthy in this context that Müller cells are capable of secreting the vascular endothelial growth factor (VEGF) [37], [38], a key player in increasing the retinal vascular permeability.
Localization (secreting) of factor
13) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.06 Pain Relevance 0
When tumors are small they secrete VEGF, which acts as a paracrine factor to induce endothelial cell proliferation and blood vessel formation, mediating tumor progression.
Localization (secrete) of factor in blood vessel associated with cancer
14) Confidence 0.03 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727886 Disease Relevance 0.73 Pain Relevance 0
Stimulation of P2X4R in microglia induces release of brain-derived neurotrophic factor [9,22,23], a factor that is crucial for producing aberrant excitability of dorsal horn neurons [9,24].
Localization (release) of factor in dorsal horn associated with dorsal horn neuron
15) Confidence 0.03 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704200 Disease Relevance 1.60 Pain Relevance 0.93
Stimulation of P2X4R in microglia induces release of brain-derived neurotrophic factor [9,22,23], a factor that is crucial for producing aberrant excitability of dorsal horn neurons [9,24].
Localization (release) of factor in dorsal horn associated with dorsal horn neuron
16) Confidence 0.03 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704200 Disease Relevance 1.59 Pain Relevance 0.93
Considering the disconnect between the large numbers of B cells activated and the small fraction that is virus infected, there may be a factor secreted by latently infected B cells that activates neighboring B cells in a paracrine manner.
Localization (secreted) of factor in B cells
17) Confidence 0.03 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.35 Pain Relevance 0.09
Eosinophils release a number of cytotoxic proteins, such as major basic protein, platelet activating factor and leukotrienes, which are responsible for the characteristic damage of the airway epithelium in allergic asthma [33,34].
Localization (release) of factor in Eosinophils associated with asthma
18) Confidence 0.03 Published 2010 Journal BMC Immunol Section Body Doc Link PMC2898835 Disease Relevance 0.97 Pain Relevance 0.36
The formation of enlarged microvessels early in the course of ascites tumor angiogenesis may relate to the fibrin stroma in which these vessels develop.38 Tumor cells implanted into the peritoneal cavity secrete vascular permeability factor and thereby render the microvasculature supplying the peritoneal lining tissues hyperpermeable.39 With respect to vascular hyperpermeability, the ascites tumor model used in the present study resembles a solid tumor model, with angiogenesis and generation of a connective tissue stroma.
Localization (secrete) of factor in connective tissue associated with pressure and volume under development, cancer and solid tumor
19) Confidence 0.02 Published 2010 Journal Int J Nanomedicine Section Body Doc Link PMC2962271 Disease Relevance 1.51 Pain Relevance 0
Although LeTx treatment does decrease the release of a number of angio-proliferative factors, including basic fibroblast growth factor (bFGF), IL-8, and VEGF from tumor cells [11] it appears that the primary effects of LeTx are mediated by a non-tumor compartment, likely endothelial cells [11], [12], [13].
Localization (release) of factor in endothelial cells associated with cancer
20) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737623 Disease Relevance 0.99 Pain Relevance 0.08

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