INT272733

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.31
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptger2, Ptgfr) plasma membrane (Ptger2, Ptgfr) signal transducer activity (Ptger2, Ptgfr)
Ptger2 (Mus musculus)
Ptgfr (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 200 91.04 High High
Inflammation 12 89.60 High High
agonist 8 56.00 Quite High
withdrawal 8 5.00 Very Low Very Low Very Low
cerebral cortex 4 5.00 Very Low Very Low Very Low
adenocard 4 5.00 Very Low Very Low Very Low
Paracetamol 4 5.00 Very Low Very Low Very Low
Kinase C 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 36 92.04 High High
Endometriosis (extended) 32 91.04 High High
INFLAMMATION 12 89.60 High High
Cancer 28 87.20 High High
Reprotox - General 1 8 39.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
are considered to be the endogenous ligands for EP and FP receptors, respectively, PGE2 can bind to the FP receptor with an affinity that is only 10–30-fold less than PGF2?
PGE2 Binding (bind) of FP receptor
1) Confidence 0.01 Published 2008 Journal Molecular and Cellular Endocrinology Section Body Doc Link PMC2694994 Disease Relevance 0.43 Pain Relevance 0.07
in the micromolar range (Lundstrom and Green, 1978; Smith et al., 1981; Rees et al., 1984; Adelantado et al., 1988) which can act locally at the site of production on prostaglandin receptors and since PGE2 can bind to the FP receptor with an affinity that is only 10–30-fold less than PGF2?
PGE2 Binding (bind) of FP receptor
2) Confidence 0.01 Published 2008 Journal Molecular and Cellular Endocrinology Section Body Doc Link PMC2694994 Disease Relevance 0.53 Pain Relevance 0.07
, which we postulated was due to the reduced affinity of PGE2 for the FP receptor compared with the native ligand PGF2?
PGE2 Binding (affinity) of FP receptor
3) Confidence 0.01 Published 2008 Journal Molecular and Cellular Endocrinology Section Body Doc Link PMC2694994 Disease Relevance 0.36 Pain Relevance 0.10
We believe this difference is due to the lower binding affinity of PGE2 for the FP receptor compared with PGF2?
PGE2 Binding (affinity) of FP receptor
4) Confidence 0.01 Published 2008 Journal Molecular and Cellular Endocrinology Section Body Doc Link PMC2694994 Disease Relevance 0 Pain Relevance 0.10

General Comments

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