INT272768

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Context Info
Confidence 0.78
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 4.73
Pain Relevance 3.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Nrxn3)
Anatomy Link Frequency
globus pallidus 3
neurons 1
brain 1
central nervous system 1
Nrxn3 (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 82 100.00 Very High Very High Very High
cocaine 11 100.00 Very High Very High Very High
drug abuse 11 100.00 Very High Very High Very High
Opioid 7 100.00 Very High Very High Very High
Nicotine 3 100.00 Very High Very High Very High
Central nervous system 14 99.68 Very High Very High Very High
Nucleus accumbens 9 96.60 Very High Very High Very High
Neurotransmitter 9 95.36 Very High Very High Very High
alcohol 37 93.52 High High
tolerance 21 62.56 Quite High
Disease Link Frequency Relevance Heat
Nicotine Addiction 19 100.00 Very High Very High Very High
Adhesions 16 100.00 Very High Very High Very High
Drug Dependence 15 100.00 Very High Very High Very High
Opiate Addiction 7 100.00 Very High Very High Very High
Obesity 148 95.68 Very High Very High Very High
Alcohol Addiction 79 93.96 High High
Eating Disorder 4 79.36 Quite High
Cardiovascular Disease 12 5.00 Very Low Very Low Very Low
Substance Withdrawal Syndrome 6 5.00 Very Low Very Low Very Low
Stress 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In mice, NRXN3 beta expression was observed in the globus pallidus when exposed to cocaine [24].
Gene_expression (expression) of NRXN3 in globus pallidus associated with cocaine
1) Confidence 0.78 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2695005 Disease Relevance 0.77 Pain Relevance 0.55
A search of publically available databases [30]–[32] did not identify an association between SNPs in NRXN3 and gene expression.
Gene_expression (expression) of NRXN3
2) Confidence 0.78 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2695005 Disease Relevance 0.61 Pain Relevance 0.26
NRXN3 is part of a family of central nervous adhesion molecules and is highly expressed in the central nervous system.
Gene_expression (expressed) of NRXN3 in central nervous system associated with central nervous system and adhesions
3) Confidence 0.78 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2695005 Disease Relevance 0.83 Pain Relevance 0.51
Many of the neuronal pathways in these sub-cortical regions of the brain in which NRXN3 is expressed are involved with learning and reward training [25].
Gene_expression (expressed) of NRXN3 in brain
4) Confidence 0.78 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2695005 Disease Relevance 0.77 Pain Relevance 0.52
Moreover, neurexin-3 is expressed in neurons projecting to brain regions involved in addictive behaviors, such as the nucleus accumbens and the striatum [144] (http://www.brain-map.org/).
Gene_expression (expressed) of neurexin-3 in neurons associated with nucleus accumbens
5) Confidence 0.05 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872348 Disease Relevance 0.56 Pain Relevance 0.48
The gene for one of the neurexin family proteins, neurexin-3, is associated with nicotine dependence [139,140], opioid dependence [141], and poly-substance abuse [142], and cocaine exposure increases neurexin-3 expression in the globus pallidus of mice [143].
Gene_expression (expression) of neurexin-3 in globus pallidus associated with addiction, drug abuse, nicotine, opioid and cocaine
6) Confidence 0.05 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872348 Disease Relevance 0.58 Pain Relevance 0.49
The gene for one of the neurexin family proteins, neurexin-3, is associated with nicotine dependence [139,140], opioid dependence [141], and poly-substance abuse [142], and cocaine exposure increases neurexin-3 expression in the globus pallidus of mice [143].
Gene_expression (expression) of neurexin-3 in globus pallidus associated with addiction, drug abuse, nicotine, opioid and cocaine
7) Confidence 0.04 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872348 Disease Relevance 0.61 Pain Relevance 0.51

General Comments

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