INT272772

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Context Info
Confidence 0.76
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 3.76
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Fto) nucleus (Fto)
Anatomy Link Frequency
colon 1
brain 1
skin 1
Fto (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 4 97.76 Very High Very High Very High
addiction 10 89.96 High High
cocaine 2 82.68 Quite High
Opioid 1 76.56 Quite High
drug abuse 2 75.32 Quite High
alcohol 1 72.96 Quite High
Central nervous system 2 70.28 Quite High
depression 2 7.36 Low Low
cytokine 2 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 375 100.00 Very High Very High Very High
Skin Cancer 2 99.28 Very High Very High Very High
Death 8 98.58 Very High Very High Very High
INFLAMMATION 4 97.76 Very High Very High Very High
Eating Disorder 1 97.76 Very High Very High Very High
Aging 249 85.80 High High
Premature Aging 6 80.36 Quite High
Opiate Addiction 1 77.00 Quite High
Drug Dependence 3 75.32 Quite High
Alcohol Addiction 1 73.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studies in mice indicate that FTO expression is particularly pronounced in regions of the brain known to regulate energy balance [28], and recent data suggest that variants in the FTO gene may regulate food intake and selection [29].
Gene_expression (expression) of FTO in brain
1) Confidence 0.76 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2695005 Disease Relevance 0.70 Pain Relevance 0.42
Although limited information is available for
               the precise cause of death for these ob/ob obese mice, it may be
               speculated that obesity-associated tumorigenesis (e.g., colon and skin cancer),
               chronic inflammation, immune deficiency and cardiovascular complications are among
               the leading causes of death in these mice [39]. 
Gene_expression (tumorigenesis) of obesity-associated in skin associated with inflammation, obesity, skin cancer and death
2) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 1.53 Pain Relevance 0.05
Although limited information is available for
               the precise cause of death for these ob/ob obese mice, it may be
               speculated that obesity-associated tumorigenesis (e.g., colon and skin cancer),
               chronic inflammation, immune deficiency and cardiovascular complications are among
               the leading causes of death in these mice [39]. 
Gene_expression (tumorigenesis) of obesity-associated in colon associated with inflammation, obesity, skin cancer and death
3) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 1.53 Pain Relevance 0.05

General Comments

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