INT272791

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Context Info
Confidence 0.48
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.18
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRF4) nucleolus (IRF4) nucleus (IRF4)
transcription factor binding (IRF4) cytoplasm (IRF4)
Anatomy Link Frequency
plasma cells 1
B cell 1
IRF4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 7 55.52 Quite High
cytokine 9 23.84 Low Low
ketamine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammatory marker 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 78 93.12 High High
Dengue 63 78.32 Quite High
Apoptosis 18 77.60 Quite High
Dengue Hemorrhagic Fever 67 68.32 Quite High
Stress 3 59.44 Quite High
Shock 12 57.04 Quite High
INFLAMMATION 8 55.52 Quite High
Hyperplasia 2 50.52 Quite High
Sprains And Strains 4 44.40 Quite Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 33 30.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Notably, IRF4 and BLNK expression are strongly represented in the in vivo meta-analysis, supporting the hypothesis that B cell stimulation, proliferation and differentiation may be a feature of acute DENV infection.
Gene_expression (expression) of IRF4 in B cell associated with infection
1) Confidence 0.48 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2886038 Disease Relevance 0.92 Pain Relevance 0
The numbers of total plasma cells (Vs38c, IRF4) and IgG-expressing plasma cells increased in the red pulp, EFZ and GC of SIV-infected animals, whereas IgA-expressing cells were present in similar proportions in the red pulp of non-infected and SIV-infected animals.
Gene_expression (expressing) of IRF4 in plasma cells
2) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695011 Disease Relevance 0.26 Pain Relevance 0.03

General Comments

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