INT272868

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Context Info
Confidence 0.27
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.15
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hdac2) enzyme binding (Hdac2) transcription factor binding (Hdac2)
cytoplasm (Hdac2)
Anatomy Link Frequency
blood 1
lungs 1
Hdac2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 29 98.32 Very High Very High Very High
cytokine 26 92.80 High High
chemokine 22 91.76 High High
antagonist 19 90.96 High High
Inflammation 156 80.36 Quite High
corticosteroid 5 46.48 Quite Low
dexamethasone 2 39.76 Quite Low
metalloproteinase 20 5.00 Very Low Very Low Very Low
Bioavailability 12 5.00 Very Low Very Low Very Low
depression 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 33 99.46 Very High Very High Very High
Disease 70 98.96 Very High Very High Very High
INFLAMMATION 189 97.92 Very High Very High Very High
Chronic Obstructive Pulmonary Disease 108 97.24 Very High Very High Very High
Malignant Neoplastic Disease 1 92.84 High High
Solid Tumor 6 92.40 High High
Skin Cancer 6 88.56 High High
Breast Cancer 5 82.12 Quite High
Pulmonary Disease 145 76.32 Quite High
Apoptosis 30 74.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alternative means of upregulating HDAC2 activity would be of great interest for potential combination therapies of the future.


Positive_regulation (upregulating) of HDAC2
1) Confidence 0.27 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 0.54 Pain Relevance 0.45
This study, which also investigated markers of HDACi efficacy, proposed that efficiency should be checked using peripheral blood rather than the tumor, and that the activity of HDAC2 should be targeted.
Positive_regulation (targeted) of HDAC2 in blood associated with cancer
2) Confidence 0.19 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2926634 Disease Relevance 1.09 Pain Relevance 0
In agreement with this, HDAC-2 activity and expression are reduced in the peripheral lungs of patients with COPD, which correlate with disease severity.86 Furthermore, as HDAC-2 activity is fundamental for functional GR?
Positive_regulation (activity) of HDAC-2 in lungs associated with chronic obstructive pulmonary disease and disease
3) Confidence 0.12 Published 2010 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2939685 Disease Relevance 0.52 Pain Relevance 0.05

General Comments

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