INT272878

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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.86
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Smad7) plasma membrane (Smad7) nucleus (Smad7)
intracellular (Smad7) protein complex (Smad7) cytoplasm (Smad7)
Smad7 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 301 99.04 Very High Very High Very High
metalloproteinase 58 98.40 Very High Very High Very High
cytokine 75 93.96 High High
chemokine 60 5.00 Very Low Very Low Very Low
antagonist 57 5.00 Very Low Very Low Very Low
Bioavailability 34 5.00 Very Low Very Low Very Low
corticosteroid 15 5.00 Very Low Very Low Very Low
Inflammatory response 15 5.00 Very Low Very Low Very Low
Infliximab 12 5.00 Very Low Very Low Very Low
Inflammatory mediators 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Disease 432 99.48 Very High Very High Very High
INFLAMMATION 319 99.04 Very High Very High Very High
Wound Healing 3 98.94 Very High Very High Very High
Stress 73 98.08 Very High Very High Very High
Emphysema 66 95.72 Very High Very High Very High
Inflammatory Bowel Disease 6 90.00 High High
Nicotine Addiction 147 82.72 Quite High
Pneumonia 12 65.52 Quite High
Apoptosis 21 64.60 Quite High
Disease 40 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Compared to let-7a precursor, both Timp3 and Smad7 were significantly inhibited by let-7a-5C precursor (Fig. 2C).
Negative_regulation (inhibited) of Smad7
1) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993968 Disease Relevance 0 Pain Relevance 0
With regard to COPD, it is not known whether Smad7 downregulation is intrinsic or due to inflammation, oxidative stress, or other factors, and what the consequences are of differential expression of TGF?
Spec (whether) Negative_regulation (downregulation) of Smad7 associated with stress, pulmonary disease and inflammation
2) Confidence 0.25 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 1.32 Pain Relevance 0.29
Maeda et al also examined the expression of I-SMADs (inhibitory SMADs), which are downstream negative regulators of R-SMAD signaling, and showed a suppression of SMAD6 and SMAD7 by SB431542 with prolonged treatment [23].
Negative_regulation (suppression) of SMAD7
3) Confidence 0.20 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2896919 Disease Relevance 0 Pain Relevance 0
1, Smad6 and Smad7, was observed to be decreased both in bronchial and alveolar tissue from patients with COPD, whereas in expression of stimulatory Smad molecules including Smad3 was unaltered (Springer et al 2004; Zandvoort et al 2006).
Negative_regulation (decreased) of Smad7 associated with pulmonary disease
4) Confidence 0.18 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 1.30 Pain Relevance 0.19
In vivo wound healing study with mice demonstrated that overexpression of Smad7 inhibits TGF?
Negative_regulation (inhibits) of Smad7 associated with wound healing
5) Confidence 0.18 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 1.23 Pain Relevance 0.24

General Comments

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