INT272882

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Context Info
Confidence 0.20
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.12
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hdac2) enzyme binding (Hdac2) transcription factor binding (Hdac2)
cytoplasm (Hdac2)
Anatomy Link Frequency
lungs 2
Hdac2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 155 99.86 Very High Very High Very High
Inflammatory response 29 92.44 High High
cytokine 26 85.40 High High
dexamethasone 2 52.00 Quite High
corticosteroid 5 38.72 Quite Low
Bioavailability 11 21.20 Low Low
chemokine 22 5.00 Very Low Very Low Very Low
metalloproteinase 20 5.00 Very Low Very Low Very Low
antagonist 19 5.00 Very Low Very Low Very Low
Infliximab 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 188 99.86 Very High Very High Very High
Disease 46 99.42 Very High Very High Very High
Chronic Obstructive Pulmonary Disease 108 98.82 Very High Very High Very High
Nicotine Addiction 59 79.96 Quite High
Stress 38 68.28 Quite High
Pulmonary Disease 145 50.00 Quite Low
Repression 2 43.80 Quite Low
Asthma 23 5.12 Low Low
Emphysema 25 5.00 Very Low Very Low Very Low
Apoptosis 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Glucocorticoid suppression of inflammatory genes requires recruitment of HDAC2 to the transcription activation complex by the glucocorticoid receptor (Ito et al 2001; Rahman et al 2004).
Positive_regulation (requires) of HDAC2 Binding (recruitment) of associated with inflammation
1) Confidence 0.20 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 0.56 Pain Relevance 0.27
In agreement with this, HDAC-2 activity and expression are reduced in the peripheral lungs of patients with COPD, which correlate with disease severity.86 Furthermore, as HDAC-2 activity is fundamental for functional GR?
Positive_regulation (fundamental) of HDAC-2 Binding (activity) of in lungs associated with chronic obstructive pulmonary disease and disease
2) Confidence 0.12 Published 2010 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2939685 Disease Relevance 0.56 Pain Relevance 0.05

General Comments

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