INT272883

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Context Info
Confidence 0.30
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 4.64
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hdac2) enzyme binding (Hdac2) transcription factor binding (Hdac2)
cytoplasm (Hdac2)
Anatomy Link Frequency
macrophage 2
Hdac2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 257 97.96 Very High Very High Very High
fibrosis 14 93.84 High High
cytokine 51 75.20 Quite High
chemokine 42 74.16 Quite High
antagonist 45 73.36 Quite High
corticosteroid 10 69.64 Quite High
dexamethasone 3 62.92 Quite High
Analgesic 2 53.84 Quite High
Bioavailability 24 31.48 Quite Low
metalloproteinase 40 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 61 99.84 Very High Very High Very High
Solid Tumor 1 99.84 Very High Very High Very High
Cancer 137 99.76 Very High Very High Very High
Pulmonary Disease 289 99.74 Very High Very High Very High
Stomach Cancer 73 98.54 Very High Very High Very High
INFLAMMATION 296 97.96 Very High Very High Very High
Apoptosis 92 96.96 Very High Very High Very High
Fibrosis 14 93.84 High High
Chronic Obstructive Pulmonary Disease 108 92.96 High High
Disease 77 92.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OCUM-2MD3 cells showed high levels of HDAC1 and HDAC2 expression compared with TMK-1 and MKN-28.
Positive_regulation (levels) of Gene_expression (expression) of HDAC2
1) Confidence 0.30 Published 2010 Journal J Exp Clin Cancer Res Section Abstract Doc Link PMC2994814 Disease Relevance 0.62 Pain Relevance 0
The availability of VPA in patients with gastric cancer may depend on patient selection based on biological parameters, such as HDAC2 overexpression.
Positive_regulation (overexpression) of Gene_expression (overexpression) of HDAC2 associated with stomach cancer
2) Confidence 0.30 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2994814 Disease Relevance 0.78 Pain Relevance 0.10
In addition, it has been reported that theophylline has a similar effect in lung macrophage cells, increasing HDAC2 expression and re-sensitising the cells to steroids (Cosio et al 2004).
Positive_regulation (increasing) of Gene_expression (expression) of HDAC2 in macrophage
3) Confidence 0.27 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 0.78 Pain Relevance 0.34
Consequently, a potential means by which to treat COPD would be to increase HDAC2 expression and activity such that steroids regain their anti-inflammatory activity.
Positive_regulation (increase) of Gene_expression (expression) of HDAC2 associated with pulmonary disease and inflammation
4) Confidence 0.27 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 0.98 Pain Relevance 0.15
A recent study by Zhu et al. showed that loss of the APC tumor suppressor induced HDAC2 expression in solid tumors [125].
Positive_regulation (induced) of Gene_expression (expression) of HDAC2 associated with cancer and solid tumor
5) Confidence 0.20 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.57 Pain Relevance 0
/Akt signaling during oxidant stress, which facilitates the modification of HDAC-2 and expression of other corepressors, remain unclear.


Positive_regulation (facilitates) of Gene_expression (expression) of HDAC-2 associated with stress
6) Confidence 0.12 Published 2010 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2939685 Disease Relevance 0.92 Pain Relevance 0.11

General Comments

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