INT272884

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Context Info
Confidence 0.43
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 23
Disease Relevance 14.55
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hdac2) enzyme binding (Hdac2) transcription factor binding (Hdac2)
cytoplasm (Hdac2)
Anatomy Link Frequency
macrophages 2
epithelial cells 1
Hdac2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 782 97.96 Very High Very High Very High
corticosteroid 25 94.24 High High
fibrosis 47 93.84 High High
dexamethasone 30 87.52 High High
cytokine 140 75.20 Quite High
chemokine 110 74.16 Quite High
antagonist 102 73.36 Quite High
Inflammatory response 145 72.96 Quite High
Analgesic 7 53.84 Quite High
Bioavailability 62 31.48 Quite Low
Disease Link Frequency Relevance Heat
Solid Tumor 106 99.84 Very High Very High Very High
Cancer 545 99.60 Very High Very High Very High
Pulmonary Disease 725 99.56 Very High Very High Very High
Targeted Disruption 32 99.44 Very High Very High Very High
Stress 195 99.20 Very High Very High Very High
Chronic Obstructive Pulmonary Disease 540 99.08 Very High Very High Very High
Stomach Cancer 253 98.54 Very High Very High Very High
Disease 433 98.12 Very High Very High Very High
INFLAMMATION 947 97.96 Very High Very High Very High
Repression 28 97.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As primary antibodies, a rabbit polyclonal HDAC1 antibody (1:5000) (Santa Cruz Biotechnology Inc., Santa Cruz, CA), rabbit polyclonal HDAC2 antibody (1:5000) (Santa Cruz), rabbit polyclonal acetyl-histone H3 (Lys 9) antibody (1:5000) (Cell Signaling, Beverly, MA), mouse monoclonal acetyl ?
Gene_expression (antibody) of HDAC2
1) Confidence 0.43 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2994814 Disease Relevance 0.34 Pain Relevance 0
HDAC1 and HDAC2 expression were evaluated by western blotting in OCUM-2MD3 cells and other gastric cancer cell lines (TMK-1, MKN-28).
Gene_expression (expression) of HDAC2 associated with stomach cancer
2) Confidence 0.39 Published 2010 Journal J Exp Clin Cancer Res Section Abstract Doc Link PMC2994814 Disease Relevance 0.57 Pain Relevance 0
The availability of VPA in patients with gastric cancer may depend on patient selection based on biological parameters, such as HDAC2 overexpression.
Gene_expression (overexpression) of HDAC2 associated with stomach cancer
3) Confidence 0.39 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2994814 Disease Relevance 0.78 Pain Relevance 0.10
OCUM-2MD3 cells showed high levels of HDAC1 and HDAC2 expression compared with TMK-1 and MKN-28.
Gene_expression (expression) of HDAC2
4) Confidence 0.39 Published 2010 Journal J Exp Clin Cancer Res Section Abstract Doc Link PMC2994814 Disease Relevance 0.61 Pain Relevance 0
Expression of HDAC1 and HDAC2 in OCUM-2MD3 cells
Gene_expression (Expression) of HDAC2
5) Confidence 0.39 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2994814 Disease Relevance 0.53 Pain Relevance 0
The HDAC2 expression was characteristically observed in the cells in mitotic phase (Figure 2).


Gene_expression (expression) of HDAC2
6) Confidence 0.39 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2994814 Disease Relevance 0.50 Pain Relevance 0
Immunohistologically, both HDAC1 and HDAC2 were expressed mainly in nuclei.
Gene_expression (expressed) of HDAC2
7) Confidence 0.39 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2994814 Disease Relevance 0.51 Pain Relevance 0
In this trial, the authors found a correlation between histone hyperacetylation and pretreatment HDAC2 expression.
Gene_expression (expression) of HDAC2
8) Confidence 0.35 Published 2010 Journal Clinical Epigenetics Section Body Doc Link PMC3020651 Disease Relevance 0.63 Pain Relevance 0
The acetylation levels correlated with VPA serum levels and could be linked to baseline HDAC2—but not HDAC6 expression.
Gene_expression (expression) of HDAC2
9) Confidence 0.35 Published 2010 Journal Clinical Epigenetics Section Body Doc Link PMC3020651 Disease Relevance 0.71 Pain Relevance 0
Based on this data, HDAC2 expression could serve as a predictive parameter to determine patients who can benefit from HDACi treatment (Munster et al. 2009a, b).
Gene_expression (expression) of HDAC2
10) Confidence 0.35 Published 2010 Journal Clinical Epigenetics Section Body Doc Link PMC3020651 Disease Relevance 0.31 Pain Relevance 0
Munster et al. reported data from two clinical trials with HDACi where they found a correlation of pretreatment HDAC2 expression and histone acetylation in tumor tissue.
Gene_expression (expression) of HDAC2 associated with cancer
11) Confidence 0.35 Published 2010 Journal Clinical Epigenetics Section Body Doc Link PMC3020651 Disease Relevance 0.31 Pain Relevance 0
In addition, it has been reported that theophylline has a similar effect in lung macrophage cells, increasing HDAC2 expression and re-sensitising the cells to steroids (Cosio et al 2004).
Gene_expression (expression) of HDAC2 in macrophage
12) Confidence 0.30 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 0.77 Pain Relevance 0.34
Consequently, a potential means by which to treat COPD would be to increase HDAC2 expression and activity such that steroids regain their anti-inflammatory activity.
Gene_expression (expression) of HDAC2 associated with pulmonary disease and inflammation
13) Confidence 0.30 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 0.97 Pain Relevance 0.15
Moreover, protein expression of HDAC2 was decreased in a similar manner in COPD patients.
Gene_expression (expression) of HDAC2 associated with pulmonary disease
14) Confidence 0.30 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 1.06 Pain Relevance 0.18
HDAC1, HDAC3, HDAC7 knockout mice are embryonic lethal, HDAC2 and HDAC4 knockouts die shortly after birth.
Gene_expression (knockouts) of HDAC2 associated with targeted disruption
15) Confidence 0.30 Published 2010 Journal Clinical Epigenetics Section Body Doc Link PMC3020651 Disease Relevance 0.46 Pain Relevance 0
Thus, the cigarette smoke/oxidant-mediated reduction in HDAC2 levels in alveolar epithelial cells and macrophages will not only increase inflammatory gene expression but will also cause a decrease in glucocorticoid function in patients with COPD.
Gene_expression (levels) of HDAC2 in epithelial cells associated with pulmonary disease and inflammation
16) Confidence 0.26 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 1.01 Pain Relevance 0.21
A recent study by Zhu et al. showed that loss of the APC tumor suppressor induced HDAC2 expression in solid tumors [125].
Gene_expression (expression) of HDAC2 associated with cancer and solid tumor
17) Confidence 0.22 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.57 Pain Relevance 0
Similarly, in models where HDAC-2 activity is compromised, GC function is reduced, and restoration or protection of HDAC-2 activity is correlated with a restoration in GC sensitivity.55,87 Therefore, there is strong evidence that the reduction in HDAC-2 activity and expression seen in patients with COPD is likely to be an important factor in the mechanisms of the relative GC insensitivity in this disease.
Gene_expression (expression) of HDAC-2 associated with chronic obstructive pulmonary disease and disease
18) Confidence 0.19 Published 2010 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2939685 Disease Relevance 0.58 Pain Relevance 0.04
Acutely, oxidative stress reduces HDAC-2 activity with a reduction in HDAC-2 protein expression seen with more chronic oxidant exposures in in vitro and in vivo models.71,78,79 This reduction in HDAC-2 activity and expression is strongly associated with oxidant-mediated covalent modifications, including hyperphosphorylation, nitration, and carbonylation, which impair protein activity and enhance proteasomal degradation.72,73,78–83 These modifications are mediated by reactive oxygen, including reactive carbonyls and reactive nitrogen species, and by kinase signaling pathways activated by oxidant stress.72,73,83 Although the exact mechanisms and pathways that regulate these modifications remain unclear, recent work has suggested that oxidants modulate HDAC-2 phosphorylation and subsequent ubiquitination followed by proteasomal degradation through a protein kinase CK2?
Gene_expression (expression) of HDAC-2 associated with stress
19) Confidence 0.19 Published 2010 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2939685 Disease Relevance 0.51 Pain Relevance 0.03
Acutely, oxidative stress reduces HDAC-2 activity with a reduction in HDAC-2 protein expression seen with more chronic oxidant exposures in in vitro and in vivo models.71,78,79 This reduction in HDAC-2 activity and expression is strongly associated with oxidant-mediated covalent modifications, including hyperphosphorylation, nitration, and carbonylation, which impair protein activity and enhance proteasomal degradation.72,73,78–83 These modifications are mediated by reactive oxygen, including reactive carbonyls and reactive nitrogen species, and by kinase signaling pathways activated by oxidant stress.72,73,83 Although the exact mechanisms and pathways that regulate these modifications remain unclear, recent work has suggested that oxidants modulate HDAC-2 phosphorylation and subsequent ubiquitination followed by proteasomal degradation through a protein kinase CK2?
Gene_expression (expression) of HDAC-2 associated with stress
20) Confidence 0.17 Published 2010 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2939685 Disease Relevance 0.44 Pain Relevance 0.03

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