INT272887

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Context Info
Confidence 0.29
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.18
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ikbkb) kinase activity (Ikbkb) cytoplasm (Ikbkb)
Anatomy Link Frequency
alveolar macrophages 1
Ikbkb (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 134 96.36 Very High Very High Very High
cytokine 36 95.84 Very High Very High Very High
chemokine 24 95.28 Very High Very High Very High
corticosteroid 5 74.48 Quite High
metalloproteinase 51 5.00 Very Low Very Low Very Low
antagonist 19 5.00 Very Low Very Low Very Low
Bioavailability 11 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
tolerance 6 5.00 Very Low Very Low Very Low
Infliximab 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 144 96.36 Very High Very High Very High
Obesity 126 90.88 High High
Insulin Resistance 34 89.36 High High
Pulmonary Disease 144 82.16 Quite High
Necrosis 4 80.48 Quite High
Cancer 7 80.12 Quite High
Diabetes Mellitus 6 77.76 Quite High
Disease 14 63.24 Quite High
Coronary Heart Disease 1 61.52 Quite High
Apoptosis 22 58.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inactivation of the inhibitor of NFkB kinase beta (IKK2), the main activator of TNF-?
Negative_regulation (inhibitor) of IKK2
1) Confidence 0.29 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 1.43 Pain Relevance 0.24
The most promising approach however, may be the inhibition of IKK-2 by small molecule inhibitors (Castro et al 2003) (Table 2), which suppress the release of inflammatory cytokines and chemokines from alveolar macrophages (Jazrawi et al 2003).
Negative_regulation (inhibition) of IKK-2 in alveolar macrophages associated with chemokine, inflammation and cytokine
2) Confidence 0.23 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 0.74 Pain Relevance 0.31

General Comments

This test has worked.

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