INT272889

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Context Info
Confidence 0.20
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.31
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Smad6) intracellular (Smad6)
Smad6 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 101 80.48 Quite High
metalloproteinase 19 70.00 Quite High
cytokine 25 51.12 Quite High
chemokine 20 5.00 Very Low Very Low Very Low
antagonist 19 5.00 Very Low Very Low Very Low
Bioavailability 12 5.00 Very Low Very Low Very Low
corticosteroid 5 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
Infliximab 4 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Disease 144 97.68 Very High Very High Very High
Emphysema 22 96.12 Very High Very High Very High
Stress 24 83.36 Quite High
INFLAMMATION 107 80.48 Quite High
Wound Healing 1 78.00 Quite High
Pneumonia 4 65.92 Quite High
Apoptosis 7 65.00 Quite High
Inflammatory Bowel Disease 2 60.80 Quite High
Nicotine Addiction 49 45.68 Quite Low
Disease 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Maeda et al also examined the expression of I-SMADs (inhibitory SMADs), which are downstream negative regulators of R-SMAD signaling, and showed a suppression of SMAD6 and SMAD7 by SB431542 with prolonged treatment [23].
Negative_regulation (suppression) of SMAD6
1) Confidence 0.20 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2896919 Disease Relevance 0 Pain Relevance 0
1, Smad6 and Smad7, was observed to be decreased both in bronchial and alveolar tissue from patients with COPD, whereas in expression of stimulatory Smad molecules including Smad3 was unaltered (Springer et al 2004; Zandvoort et al 2006).
Negative_regulation (decreased) of Smad6 associated with pulmonary disease
2) Confidence 0.16 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 1.31 Pain Relevance 0.19

General Comments

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