INT272918

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Context Info
Confidence 0.03
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.24
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SELE) cell adhesion (SELE) plasma membrane (SELE)
Anatomy Link Frequency
endothelial cells 2
mast cell 2
SELE (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 27 99.28 Very High Very High Very High
qutenza 4 98.68 Very High Very High Very High
substance P 35 97.04 Very High Very High Very High
cytokine 37 94.92 High High
Pain 2 89.96 High High
Inflammation 140 87.08 High High
unmyelinated 4 74.24 Quite High
chemokine 20 55.28 Quite High
corticosteroid 7 55.20 Quite High
Catecholamine 1 54.52 Quite High
Disease Link Frequency Relevance Heat
Adhesions 5 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 2 96.32 Very High Very High Very High
Pulmonary Disease 144 90.56 High High
Pressure And Volume Under Development 1 90.52 High High
Injury 11 89.96 High High
Pain 2 89.96 High High
Erythema 1 89.72 High High
INFLAMMATION 141 87.08 High High
Wound Healing 3 85.08 High High
Infection 6 84.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, capsaicin (which releases neuropeptides from nerves) applied to human skin induces the release of chymase within 6 hours and the induction of E-selectin in adjacent microvascular endothelium, events consistent with release of substance P from axons and subsequent stimulation of cytokine-mediated mast cell interaction with endothelial cells.
Positive_regulation (induces) of Positive_regulation (induction) of E-selectin in mast cell associated with qutenza, neuropeptide, cytokine and substance p
1) Confidence 0.03 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877069 Disease Relevance 1.02 Pain Relevance 0.86
Shen and co-workers (1996) have shown that cigarette smoke condensate induces the expression of a subset of cell adhesion molecules, such as intercellular adhesion molecule (ICAM-1), endothelial leukocyte adhesion molecule 1 (ELAM-1), and vascular cell adhesion molecule (VCAM-1) in human umbilical vascular endothelial cells associated with an increase in the binding activity of NF-?
Positive_regulation (subset) of Positive_regulation (endothelial) of adhesion molecule 1 in endothelial cells associated with adhesions
2) Confidence 0.02 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 1.22 Pain Relevance 0.10

General Comments

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