INT272927

Context Info Confidence 0.16 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.53 Pain Relevance 0.14

mitochondrion (Mapk14) cell morphogenesis (Mapk14) intracellular (TNF) extracellular matrix organization (TNF) response to stress (Mapk14) cytoplasm (Mapk14)

Mapk14 (Mus musculus) TNF (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 100 58.44 cytokine 25 57.20 chemokine 20 53.72 antagonist 19 37.80 metalloproteinase 19 5.00 Bioavailability 11 5.00 corticosteroid 5 5.00 Inflammatory response 5 5.00 Infliximab 4 5.00 Inflammatory mediators 2 5.00

Disease Link Frequency Relevance Heat Stress 23 99.46 Pulmonary Disease 144 88.88 Injury 8 80.00 INFLAMMATION 106 58.44 Nicotine Addiction 49 5.00 Emphysema 22 5.00 Disease 13 5.00 Asthma 12 5.00 Bronchitis 9 5.00 Apoptosis 7 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Results from studies in mice and cell lines suggest that oxidative stress activates MAPK p42/44 and p38 which stimulates the expression of TNF?

p38 Positive_regulation (stimulates) of Gene_expression (expression) of TNF associated with stress

1) Confidence 0.16 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 0.53 Pain Relevance 0.14

General Comments

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