INT27293

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.53
First Reported 1989
Last Reported 2010
Negated 3
Speculated 4
Reported most in Body
Documents 21
Total Number 25
Disease Relevance 15.73
Pain Relevance 1.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (SOD1) peroxisome (SOD1) protein complex (SOD1)
cytoplasm (SOD1) cytosol (SOD1) extracellular space (SOD1)
Anatomy Link Frequency
lung 3
plasma 1
liver 1
pancreas 1
anterior 1
SOD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
fluoxetine 3 99.38 Very High Very High Very High
bradykinin 6 99.00 Very High Very High Very High
Inflammation 129 98.72 Very High Very High Very High
diclofenac 80 93.32 High High
Neurotransmitter 1 93.12 High High
adenocard 6 92.28 High High
noradrenaline 1 91.28 High High
anesthesia 10 90.72 High High
depression 8 89.00 High High
cytokine 43 87.84 High High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 12 100.00 Very High Very High Very High
Obesity 108 99.52 Very High Very High Very High
Fever 2 99.52 Very High Very High Very High
Stress 331 99.40 Very High Very High Very High
Poisoning 2 99.20 Very High Very High Very High
Diabetes Mellitus 366 99.04 Very High Very High Very High
Apoptosis 209 98.88 Very High Very High Very High
INFLAMMATION 155 98.72 Very High Very High Very High
Heart Rate Under Development 68 98.68 Very High Very High Very High
Cancer 232 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The TAS level and SOD activity can be affected by age.
Regulation (affected) of SOD
1) Confidence 0.53 Published 2010 Journal Journal of Periodontal & Implant Science Section Body Doc Link PMC2931304 Disease Relevance 0.94 Pain Relevance 0.04
Effects of a newly introduced polyoxyethylene-modified superoxide dismutase (SOD-POE) on reperfusion induced arrhythmias were examined in the pentobarbital anesthetized rat.
Spec (examined) Regulation (Effects) of SOD
2) Confidence 0.43 Published 1989 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 2593377 Disease Relevance 0 Pain Relevance 0
First, preventive anti-oxidants inhibit the formation of free radicals, including SOD, carotenoids, catalase, glutathione peroxidase, transferrin, albumin, and haptoglobin.
Regulation (formation) of SOD
3) Confidence 0.39 Published 2010 Journal Journal of Periodontal & Implant Science Section Body Doc Link PMC2931304 Disease Relevance 0.23 Pain Relevance 0
In this study, although the changes in the TAS level and SOD activity were different among individuals, the measurements in both groups decreased immediately after non-surgical treatment.
Regulation (changes) of SOD
4) Confidence 0.39 Published 2010 Journal Journal of Periodontal & Implant Science Section Body Doc Link PMC2931304 Disease Relevance 0.76 Pain Relevance 0
SOD1 and SOD2 polymorphisms may affect SOD activity.
Spec (may) Regulation (affect) of SOD
5) Confidence 0.26 Published 2008 Journal BMC Med Genet Section Abstract Doc Link PMC2386118 Disease Relevance 0.74 Pain Relevance 0
As SOD is very sensitive to oxygen, high temperature and acidity, the melon juice concentrate has to be coated.
Regulation (sensitive) of SOD associated with fever
6) Confidence 0.26 Published 2009 Journal Nutr J Section Body Doc Link PMC2757026 Disease Relevance 0.60 Pain Relevance 0
This particular mutation was chosen, because it does not affect the activity of SOD1.
Neg (not) Regulation (affect) of SOD1
7) Confidence 0.25 Published 2007 Journal BMC Infect Dis Section Body Doc Link PMC2211486 Disease Relevance 1.46 Pain Relevance 0.21
RESULTS: Cytoplasmic values of manganese SOD, catalase, and glutathione peroxidase were decreased in pancreatic cells from chronic pancreatitis specimens when compared with normal pancreas.
Regulation (values) of SOD in pancreas
8) Confidence 0.24 Published 2003 Journal Pancreas Section Body Doc Link 12499913 Disease Relevance 0 Pain Relevance 0
Changes in SOD activity
Regulation (Changes) of SOD
9) Confidence 0.23 Published 2010 Journal Journal of Periodontal & Implant Science Section Body Doc Link PMC2931304 Disease Relevance 0.07 Pain Relevance 0
Effects of a newly introduced polyoxyethylene-modified superoxide dismutase (SOD-POE) with prolonged plasma half life (10 h) on reperfusion induced arrhythmias were examined using a 15 min left anterior descending coronary artery (LAD) occlusion followed by reperfusion in the isolated perfused rat and guinea-pig hearts.
Spec (examined) Regulation (Effects) of SOD in anterior
10) Confidence 0.16 Published 1989 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 2778803 Disease Relevance 0 Pain Relevance 0
We have found that the change in HSP70 RNA expression is positively correlated to the change of both Mn-SOD (r = 0.93; P = 0.001; 95% CI: 0.98 to 0.73; ES 0.71) and bcl-2 transcripts (r = 0.84; P = 0.002; 95% CI: 0.96 to 0.45; ES 0.2) after marathon (Fig. 5).
Regulation (change) of SOD
11) Confidence 0.14 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2893521 Disease Relevance 0 Pain Relevance 0
For instance, stautosporine, a protein kinase inhibitor, did not affect the mRNA levels of SOD1 and SOD2, but decreased protein and activity levels of both enzymes [48].
Neg (not) Regulation (affect) of SOD1
12) Confidence 0.13 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896885 Disease Relevance 0.30 Pain Relevance 0.17
It is known to up regulate the activity of SOD [16].
Regulation (regulate) of SOD
13) Confidence 0.12 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2127225 Disease Relevance 0.52 Pain Relevance 0.14
Vitamin C treatment on the radiation-exposed groups resulted in significantly increased SOD and GSH-Px activities.
Regulation (resulted) of SOD
14) Confidence 0.11 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2787304 Disease Relevance 0.30 Pain Relevance 0
The effects of medicinal margarite extract and recombinant human superoxide dismutase (r-h SOD) on acute paraquat intoxication were examined in the rat lung.
Spec (examined) Regulation (effects) of r-h SOD in lung associated with poisoning
15) Confidence 0.10 Published 1994 Journal Circ. Shock Section Abstract Doc Link 7895320 Disease Relevance 0.10 Pain Relevance 0.09
B will act to prevent cell death by a number of mechanisms, some of them potentially affecting ROS-mediated sustained JNK activation, such as specifically the reported up-regulation of SOD-2 (that is, the mitochondrial SOD isoform), in TNF-dependent cell death [210].
Regulation (regulation) of SOD associated with death
16) Confidence 0.09 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 1.11 Pain Relevance 0
Also, there was no change in intracellular SOD activity immediately after hypericin irradiation.
Neg (no) Regulation (change) of SOD
17) Confidence 0.07 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2852855 Disease Relevance 0.96 Pain Relevance 0
RPE caused significantly increased MDA levels, and decreased GPx and SOD activity in lung tissue in our study.
Regulation (activity) of SOD in lung associated with heart rate under development
18) Confidence 0.07 Published 2008 Journal J Cardiothorac Surg Section Body Doc Link PMC2583976 Disease Relevance 1.11 Pain Relevance 0.09
The effects of acute glycemia on plasma nitric oxide (NO; nitrite plus nitrate) levels, Cu-Zn Superoxide dismutase (Cu-Zn SOD) activity and thiobarbituric acid-reactive substances (TBARS) levels were studied in age-matched female subjects before and two hours after glucose loading.
Regulation (effects) of Cu-Zn Superoxide dismutase in plasma
19) Confidence 0.06 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350146 Disease Relevance 1.42 Pain Relevance 0.31
SOD activity is undoubtedly important to the regulation of oxidative status in diabetes.
Regulation (regulation) of SOD associated with diabetes mellitus
20) Confidence 0.06 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1131912 Disease Relevance 0.87 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox