INT272940

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Context Info
Confidence 0.37
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.57
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Myog) nucleus (Myog) DNA binding (Myog)
Anatomy Link Frequency
muscle 6
Myog (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 31 81.20 Quite High
cytokine 15 77.92 Quite High
tolerance 4 59.08 Quite High
fibrosis 6 23.60 Low Low
corticosteroid 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Frailty 58 99.50 Very High Very High Very High
Apoptosis 17 97.60 Very High Very High Very High
Cancer 48 94.04 High High
Body Weight 9 88.76 High High
Dyspnea 5 88.36 High High
Injury 12 87.68 High High
Colon Cancer 1 85.28 High High
INFLAMMATION 32 81.20 Quite High
Muscular Atrophy 20 78.72 Quite High
Pulmonary Disease 98 72.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We observed an increase of myogenin expression and Akt phosphorylation in the soleus muscles on day 3 after glycerol injection, but it was suppressed in As2O3-treated mice compared with control mice (Figure 8).
Positive_regulation (increase) of Gene_expression (expression) of myogenin in muscles
1) Confidence 0.37 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920914 Disease Relevance 0.24 Pain Relevance 0.04
In C26 hosts, muscle wasting is also associated with increased Pax7 expression and reduced myogenin levels.
Positive_regulation (increased) of Gene_expression (expression) of myogenin in muscle associated with frailty
2) Confidence 0.21 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2965098 Disease Relevance 0.80 Pain Relevance 0.04
The beneficial effects of exercise may, at least partly, be brought about by an increase in the expression of myogenin (Siu, Donley et al 2004), a reduction of the occurrence of apoptosis (Siu, Bryner et al 2004), and suppression of the muscle specific ubiquitin ligase atrogin (Leger et al 2006).
Positive_regulation (increase) of Gene_expression (expression) of myogenin in muscle associated with apoptosis
3) Confidence 0.06 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695204 Disease Relevance 0.52 Pain Relevance 0.11

General Comments

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