INT272945

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Context Info
Confidence 0.35
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.10
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Myod1) nucleus (Myod1) enzyme binding (Myod1)
DNA binding (Myod1) transcription factor binding (Myod1) cytoplasm (Myod1)
Anatomy Link Frequency
myoblast 1
Myod1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 56 80.88 Quite High
cytokine 12 5.00 Very Low Very Low Very Low
corticosteroid 8 5.00 Very Low Very Low Very Low
tolerance 6 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 44 99.24 Very High Very High Very High
Pulmonary Disease 196 95.60 Very High Very High Very High
Frailty 76 95.12 Very High Very High Very High
Atrophic Muscular Disorders 2 92.80 High High
Targeted Disruption 4 85.28 High High
INFLAMMATION 58 80.88 Quite High
Muscular Atrophy 10 77.68 Quite High
Apoptosis 26 68.32 Quite High
Obesity 4 35.88 Quite Low
Fatigue 52 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, MyoD becomes more prone to degradation by the ubiquitin proteasome pathway when it forms dimers with inhibitors of differentiation (Id) proteins (Reid 2005).
Protein_catabolism (degradation) of MyoD
1) Confidence 0.35 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695204 Disease Relevance 0.70 Pain Relevance 0
In addition, it has been reported in cell culture studies that hypoxia inhibits myoblast differentiation by degradation of MyoD, a myogenic transcription factor, via the ubiquitin proteasome pathway (Di Carlo et al 2004).
Protein_catabolism (degradation) of MyoD in myoblast associated with hypoxia
2) Confidence 0.23 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695204 Disease Relevance 1.40 Pain Relevance 0.08

General Comments

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