INT272949

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Context Info
Confidence 0.36
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 5.31
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Myod1) nucleus (Myod1) enzyme binding (Myod1)
DNA binding (Myod1) transcription factor binding (Myod1) cytoplasm (Myod1)
Anatomy Link Frequency
skeletal muscle 2
cardiac muscle 1
diaphragm 1
muscle 1
soleus 1
Myod1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 18 83.92 Quite High
fibrosis 75 77.04 Quite High
Potency 1 27.36 Quite Low
tolerance 12 24.72 Low Low
Calcium channel 4 24.12 Low Low
Inflammation 94 5.00 Very Low Very Low Very Low
cytokine 29 5.00 Very Low Very Low Very Low
imagery 14 5.00 Very Low Very Low Very Low
corticosteroid 12 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Disease 294 96.96 Very High Very High Very High
Muscular Atrophy 32 96.48 Very High Very High Very High
Targeted Disruption 18 96.48 Very High Very High Very High
Cardiomyopathy 126 96.32 Very High Very High Very High
Muscular Dystrophy 280 93.12 High High
Embryonal Carcinoma 23 90.00 High High
Apoptosis 42 88.96 High High
Muscle Disease 2 81.76 Quite High
Atrophic Muscular Disorders 3 81.04 Quite High
Disease 36 79.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
During differentiation, phosphorylated ERK, occurring at high levels over days 1–3, progressively declines concomitantly with Pax7 reduction and myogenin and MyoD increases (Fig.
Positive_regulation (increases) of MyoD
1) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965098 Disease Relevance 0.26 Pain Relevance 0
The double mdx/MyoD knockout mice show pronounced myopathic changes caused by the reduction in the skeletal muscles ability to regenerate as the satellite cells that are the resident stem cell population require MyoD for their proper differentiation [65].
Positive_regulation (require) of MyoD in skeletal muscles associated with targeted disruption
2) Confidence 0.32 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC3024556 Disease Relevance 0.96 Pain Relevance 0.10
The relatively mild phenotype and near normal life span of the mdx mouse has prompted the generation of double mutants such as the mdx/utrophin and the mdx/MyoD mice, both of which have a far more severe skeletal and cardiac muscle phenotype to model the development of cardiomyopathy.
Positive_regulation (generation) of MyoD in cardiac muscle associated with cardiomyopathy
3) Confidence 0.32 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC3024556 Disease Relevance 1.44 Pain Relevance 0
Myogenic regulatory factors, such as MyoD, play an important role in satellite cell differentiation and hence regenerative capacity of the muscle (Charge et al 2004).
Positive_regulation (regenerative) of MyoD in muscle
4) Confidence 0.17 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695204 Disease Relevance 1.18 Pain Relevance 0
Elevation of these proteins may thus contribute to the reduced abundance of MyoD protein but not mRNA in the soleus and diaphragm of emphysematous hamsters (Degens et al 2004), indicating MyoD breakdown rather than reduced transcription.
Positive_regulation (indicating) of MyoD in diaphragm
5) Confidence 0.17 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695204 Disease Relevance 0.60 Pain Relevance 0
As shown in Figures 6C and 6D, treatment also induced the mRNA genes involved in skeletal muscle morphogenesis, myogenin mRNA (Fig. 6C) and MyoD mRNA (Fig. 6D).
Positive_regulation (induced) of MyoD in skeletal muscle
6) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964328 Disease Relevance 0.26 Pain Relevance 0.04
Elevation of these proteins may thus contribute to the reduced abundance of MyoD protein but not mRNA in the soleus and diaphragm of emphysematous hamsters (Degens et al 2004), indicating MyoD breakdown rather than reduced transcription.
Positive_regulation (indicating) of MyoD in soleus
7) Confidence 0.06 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695204 Disease Relevance 0.60 Pain Relevance 0

General Comments

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