INT272998

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Context Info
Confidence 0.04
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CYP2D6) extracellular space (IL33) small molecule metabolic process (CYP2D6)
oxidoreductase activity (CYP2D6) extracellular region (IL33) endoplasmic reticulum (CYP2D6)
IL33 (Homo sapiens)
CYP2D6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Desipramine 3 93.48 High High
Duloxetine 12 91.36 High High
Bioavailability 1 63.32 Quite High
Pain 6 29.76 Quite Low
Neurotransmitter 1 27.36 Quite Low
Dopamine 3 22.44 Low Low
sSRI 14 5.00 Very Low Very Low Very Low
depression 14 5.00 Very Low Very Low Very Low
sNRI 13 5.00 Very Low Very Low Very Low
antidepressant 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 6 29.76 Quite Low
Chronic Renal Failure 1 21.52 Low Low
Disorders Of Creatine Metabolism 1 10.88 Low Low
Depression 42 5.00 Very Low Very Low Very Low
Vomiting 10 5.00 Very Low Very Low Very Low
Anxiety Disorder 9 5.00 Very Low Very Low Very Low
Recurrence 7 5.00 Very Low Very Low Very Low
Disorder Of Lipid Metabolism 6 5.00 Very Low Very Low Very Low
Sleep Disorders 5 5.00 Very Low Very Low Very Low
Disease 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These were significantly greater than the increases observed with DVS co-administration (22% and 19%, respectively), suggesting that DVS is not a clinically significant inhibitor of CYP2D6 activity.
DVS Negative_regulation (inhibitor) of CYP2D6
1) Confidence 0.04 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695227 Disease Relevance 0 Pain Relevance 0.25

General Comments

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