INT273015

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Context Info
Confidence 0.39
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 3.62
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Icam5)
Anatomy Link Frequency
T-cells 2
Icam5 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 2 85.56 High High
Pain 2 69.48 Quite High
headache 4 67.92 Quite High
cytokine 46 58.40 Quite High
Hippocampus 24 57.84 Quite High
Potency 2 51.84 Quite High
Inflammation 6 36.32 Quite Low
tolerance 4 23.84 Low Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Substantia nigra 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Convulsion 173 97.36 Very High Very High Very High
Adhesions 12 96.92 Very High Very High Very High
Dengue 128 94.68 High High
Infection 44 94.36 High High
Dengue Hemorrhagic Fever 62 87.40 High High
Hemorrhage 6 80.00 Quite High
Viral Meningitis 6 77.00 Quite High
Leukopenia 2 75.24 Quite High
Disease 20 70.68 Quite High
Pain 2 69.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DC-SIGN has a high affinity for ICAM3 which is expressed in activating T-cells.
Gene_expression (expressed) of ICAM3 in T-cells
1) Confidence 0.39 Published 2009 Journal Virol J Section Abstract Doc Link PMC2789730 Disease Relevance 2.54 Pain Relevance 0.17
The demonstration of dose-dependent convulsions in the dosage range 100–150 mg/kg in this study is consistent with the results of previous studies in mice.7,8,30 In addition, the CD50 values of 103 and 110 mg/kg obtained in this study for bupropion HCl and bupropion HBr treatments, respectively, are similar to the values of 116.72 (CI: 107.95, 126.20) and 119.7 (CI: 104.1, 137.6) mg/kg reported previously for IP bupropion HCl administration in mice.7,30
Gene_expression (values) of CD50 associated with convulsion
2) Confidence 0.36 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695230 Disease Relevance 0.57 Pain Relevance 0.05
DC-SIGN has a high affinity to the ICAM3 molecules expressed on T-cells with a complicated system of cross talk that can lead to a variety of outcomes[22].
Gene_expression (expressed) of ICAM3 in T-cells
3) Confidence 0.30 Published 2009 Journal Virol J Section Body Doc Link PMC2789730 Disease Relevance 0.51 Pain Relevance 0.07

General Comments

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