INT273017

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Context Info
Confidence 0.08
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Title
Documents 1
Total Number 1
Disease Relevance 0.35
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDE1B, PDE11A) signal transduction (PDE1B, PDE11A) cytoplasm (PDE1B, PDE11A)
nucleolus (PDE1B) nucleus (PDE1B) cellular_component (PDE11A)
PDE1B (Homo sapiens)
PDE11A (Homo sapiens)
Pain Link Frequency Relevance Heat
antidepressant 17 100.00 Very High Very High Very High
depression 8 100.00 Very High Very High Very High
Desipramine 5 33.08 Quite Low
fluoxetine 5 32.48 Quite Low
Disease Link Frequency Relevance Heat
Depression 44 100.00 Very High Very High Very High
Cancer 2 5.00 Very Low Very Low Very Low
Pituitary Cancer 1 5.00 Very Low Very Low Very Low
Hyperplasia 1 5.00 Very Low Very Low Very Low
Pituitary Acth Hypersecretion 1 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 1 5.00 Very Low Very Low Very Low
Mental Disorders 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Association of PDE11A global haplotype with major depression and antidepressant drug response

Cyclic nucleotide phosphodiesterases (PDEs) hydrolyze the intracellular second messengers cAMP and cGMP to their corresponding monophosphates.

PDEs Binding (Association) of PDE11A associated with antidepressant and depression
1) Confidence 0.08 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Title Doc Link PMC2695232 Disease Relevance 0.35 Pain Relevance 0.14

General Comments

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