INT273035

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 3.33
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
vessels 1
regulatory T cell 1
Bsbob (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropeptide 39 99.34 Very High Very High Very High
adenocard 6 99.34 Very High Very High Very High
Central nervous system 69 95.08 Very High Very High Very High
Neurotransmitter 6 86.44 High High
Multiple sclerosis 69 83.28 Quite High
Inflammation 36 79.48 Quite High
Inflammatory mediators 6 28.80 Quite Low
Substantia nigra 12 5.00 Very Low Very Low Very Low
Spinal cord 9 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autoimmune Disease 45 98.94 Very High Very High Very High
Pathologic Processes 3 98.16 Very High Very High Very High
Neurodegenerative Disease 24 96.36 Very High Very High Very High
Nociception 6 89.84 High High
Hypoxia 9 88.28 High High
Multiple Sclerosis 84 83.28 Quite High
Motor Neuron Diseases 42 82.96 Quite High
Chronic Fatigue Syndrome 33 82.64 Quite High
Disease 69 82.56 Quite High
Fatigue 33 80.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PACAP and VIP, as potent activators of adenylate cyclase (AC), have a key role in cyclic adenosine monophosphate (cAMP) production affecting BBB/BSB function along with regulatory T cell (Treg) and other immune functions.
Regulation (affecting) of BSB in regulatory T cell associated with adenocard
1) Confidence 0.01 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695238 Disease Relevance 0.82 Pain Relevance 0.22
Virchow–Robin spaces (VRS) are perivascular compartments surrounding small vessels within the CNS which contribute to BBB and BSB integrity and modulate immune responses.90 VRS contain microglia and these cells are known to be influenced by PACAP and VIP in immunoregulation.8 Autoimmunity of these VNs or their receptors would be expected to affect BBB/BSB and VRS function and therefore may contribute to the etiology of neuropsychiatric-related neurodegenerative and other conditions by affecting CNS and immunological homeostasis.
Regulation (affect) of BSB in vessels associated with autoimmune disease, neuropeptide, central nervous system and neurodegenerative disease
2) Confidence 0.01 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695238 Disease Relevance 1.45 Pain Relevance 0.39
Autoimmunity affecting these VNs would likely have a detrimental effect on BBB and BSB functioning arguably predisposing to further pathological processes.
Regulation (effect) of BSB associated with pathologic processes, autoimmune disease and neuropeptide
3) Confidence 0.01 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Abstract Doc Link PMC2695238 Disease Relevance 1.06 Pain Relevance 0.54

General Comments

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