INT273040

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Context Info
Confidence 0.23
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.69
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bax) endoplasmic reticulum (Bax) intracellular (Bax)
cytoplasm (Bax) lipid binding (Bax) cytosol (Bax)
Anatomy Link Frequency
astrocytes 1
Vip (Mus musculus)
Bax (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 23 90.16 High High
medulla 1 69.12 Quite High
ischemia 1 56.48 Quite High
Inflammation 12 52.52 Quite High
Neuropeptide 13 50.00 Quite Low
Multiple sclerosis 23 38.84 Quite Low
Substantia nigra 4 5.00 Very Low Very Low Very Low
Spinal cord 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 8 98.64 Very High Very High Very High
Autoimmune Disease 15 98.56 Very High Very High Very High
Dementia 9 98.00 Very High Very High Very High
Cognitive Disorder 1 90.64 High High
Vascular Dementia 1 82.56 Quite High
Syndrome 2 77.96 Quite High
Chronic Fatigue Syndrome 11 74.80 Quite High
Motor Neuron Diseases 14 69.88 Quite High
Cv Unclassified Under Development 1 56.48 Quite High
Pathologic Dilatation 1 54.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fronto-temporal dementia (FTD) is a neurodegenerative disease in which a vascular component is suggested and immunoreactivity of Bax, a proapoptotic protein regulated in part by PACAP/VIP in astrocytes, suggests a role for autoimmunity in the pathology of FTD.44 Astrogliosis in FTD corresponds with SPECT hypoperfusion, suggesting that astrocyte disruption may be related to disturbances of cerebral perfusion in FTD.45 Cognitive dysfunction is associated with reduced cerebral blood flow in different types of dementia.46 Moreover VRS dilatation associated with microvessel abnormality may contribute to the diagnosis of vascular dementias.47 Changes in social behavior occur in cerebrovascular comprise and may result from an FTD-like syndrome.48 Similarly, reduction in cortical blood flow has been identified in CFS patients;49,50 however these findings were not replicated in a study of twins with CFS.51 FTD however is recognized in ALS.91
VIP Regulation (regulated) of Bax in astrocytes associated with chronic fatigue syndrome, vascular dementia, cognitive disorder, autoimmune disease, dementia, syndrome, neurodegenerative disease and motor neuron diseases
1) Confidence 0.23 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695238 Disease Relevance 1.69 Pain Relevance 0.13

General Comments

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