INT273046

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Context Info
Confidence 0.20
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.14
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Vip, Adcyap1) signal transduction (Adcyap1) extracellular space (Adcyap1)
Anatomy Link Frequency
neuronal 2
Vip (Mus musculus)
Adcyap1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 2 100.00 Very High Very High Very High
Substantia nigra 4 97.10 Very High Very High Very High
Neuropeptide 13 50.00 Quite Low
Spinal cord 3 26.32 Quite Low
Multiple sclerosis 23 12.80 Low Low
Central nervous system 23 5.00 Very Low Very Low Very Low
Inflammation 12 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 23 100.00 Very High Very High Very High
INFLAMMATION 19 100.00 Very High Very High Very High
Drug Induced Neurotoxicity 1 98.60 Very High Very High Very High
Stress 1 95.56 Very High Very High Very High
Apoptosis 2 94.96 High High
Parkinson's Disease 1 89.76 High High
Autoimmune Disease 15 81.08 Quite High
Fatigue 11 75.48 Quite High
Increased Venous Pressure Under Development 2 59.32 Quite High
Neuromyelitis Optica 1 38.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PACAP activates receptors of PAC1R, VPAC1R, and VPAC2R families, and PACAP has been identified widely in the brain including the SN as well as in other organs and blood cells.56 Moreover, PACAP has been shown to be effective in treatment in rat models of PD.57 Both PACAP and VIP have neuroprotective effects in PD models by inhibiting the production of inflammatory mediators.58 PACAP specifically protects against the neurotoxicity induced by rotenone59 as well as protecting against oxidative stress-induced apoptosis.60 In a murine model for PD, Delgado and Ganea61 note that the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) activates microglia and promotes dopaminergic neuronal loss.
VIP Negative_regulation (inhibiting) of Gene_expression (production) of PACAP in neuronal associated with parkinson's disease, stress, inflammatory mediators, drug induced neurotoxicity, substantia nigra, apoptosis and disease
1) Confidence 0.20 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695238 Disease Relevance 1.14 Pain Relevance 0.21

General Comments

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