INT273047

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Context Info
Confidence 0.04
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.41
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Aqp4) extracellular region (Sct) plasma membrane (Aqp4)
protein complex (Aqp4) transmembrane transport (Aqp4) cytoplasm (Aqp4)
Anatomy Link Frequency
pia mater 1
Aqp4 (Mus musculus)
Sct (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropeptide 13 50.00 Quite Low
Central nervous system 23 49.84 Quite Low
medulla 1 28.80 Quite Low
ischemia 1 16.16 Low Low
Inflammation 12 12.20 Low Low
Substantia nigra 4 11.76 Low Low
Multiple sclerosis 23 5.00 Very Low Very Low Very Low
Spinal cord 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuromyelitis Optica 1 100.00 Very High Very High Very High
Motor Neuron Diseases 14 92.24 High High
Dementia 9 91.08 High High
Chronic Fatigue Syndrome 11 90.80 High High
Syndrome 2 84.36 Quite High
Vascular Dementia 1 80.16 Quite High
Cognitive Disorder 1 71.72 Quite High
Increased Venous Pressure Under Development 2 67.44 Quite High
Autoimmune Disease 15 63.92 Quite High
Neurodegenerative Disease 8 56.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The astroglial water channel aquaporin (AQP4) is essential for the maintenance of BBB integrity.52 Antibodies to AQP4 have a highly specific role in neuromyelitis optica (NMO) and characteristically bind to cerebral microvessels, pia mater and VRSs.53 Secretin is important for other aquaporin expression via vasopressin, secretin receptor-null mice for example have reduced renal expression of AQP2 and AQP4.54 Thus VIP impairment may influence water channel function.
AQP4 Binding (bind) of Secretin in pia mater associated with neuromyelitis optica
1) Confidence 0.04 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695238 Disease Relevance 1.41 Pain Relevance 0

General Comments

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