INT273054

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.14
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.66
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Bad) cell proliferation (Bad) cytosol (Bad)
mitochondrion (Bad) cytoplasm (Bad)
Anatomy Link Frequency
neurons 2
Bad (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 1 92.20 High High
ischemia 45 88.28 High High
Inflammation 19 76.72 Quite High
Hippocampus 2 42.76 Quite Low
cINOD 15 41.36 Quite Low
Glutamate 1 34.80 Quite Low
adenocard 1 14.24 Low Low
agonist 26 5.00 Very Low Very Low Very Low
cva 10 5.00 Very Low Very Low Very Low
Pyramidal cell 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 15 100.00 Very High Very High Very High
Middle Cerebral Artery Infarction 14 99.36 Very High Very High Very High
Stroke 46 97.16 Very High Very High Very High
Apoptosis 116 96.64 Very High Very High Very High
Death 20 90.56 High High
Neurodegenerative Disease 8 89.60 High High
Hypoxia 15 88.60 High High
Cv Unclassified Under Development 31 88.28 High High
Stress 14 88.24 High High
Adhesions 1 82.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
augments binding and sequestration of Bad, and thereby reduces interference of Bcl-2 and Bcl-xl protective actions by Bad [58–61].
Positive_regulation (augments) of Bad Binding (binding) of
1) Confidence 0.14 Published 2010 Journal PPAR Research Section Body Doc Link PMC2938460 Disease Relevance 0.61 Pain Relevance 0
Results from immunoprecipitation experiments confirm enhanced Bad binding by 14-3-3?
Positive_regulation (enhanced) of Bad Binding (binding) of
2) Confidence 0.13 Published 2010 Journal PPAR Research Section Body Doc Link PMC2938460 Disease Relevance 0.48 Pain Relevance 0
Administering melatonin prior to MCAO or at the onset of reperfusion restores the injury-induced reduction in phosphorylated AKT (p-AKT), p-Bad and Bcl-XL levels and the binding of p-Bad and 14-3-3 as well as decreases caspase-3 activation.38,39 Treatment of melatonin also suppresses the immunoreactivity of cytosolic cytochrome c oxdiase in the ischemic cortex four and 24 hours after MCAO.40 To investigate whether melatonin directly inhibits neuronal apoptosis after hypoxia/ischemia, mouse striatal neurons are cultured and subjected to oxygen and glucose deprivation (OGD).
Positive_regulation (restores) of p-Bad Binding (binding) of in neurons associated with hypoxia, middle cerebral artery infarction, ischemia, injury and neurodegenerative disease
3) Confidence 0.01 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695239 Disease Relevance 1.57 Pain Relevance 0.16

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox