INT273063

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.72
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Fas, Bcl2) nucleus (Fas, Bcl2) cytoplasm (Fas, Bcl2)
mitochondrion (Bcl2) growth (Bcl2) cell death (Bcl2)
Fas (Rattus norvegicus)
Bcl2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 1 100.00 Very High Very High Very High
ischemia 1 58.68 Quite High
Potency 1 55.20 Quite High
Nerve growth factor 2 44.96 Quite Low
Dopamine 18 5.00 Very Low Very Low Very Low
monoamine 6 5.00 Very Low Very Low Very Low
Serotonin 5 5.00 Very Low Very Low Very Low
sSRI 4 5.00 Very Low Very Low Very Low
sNRI 2 5.00 Very Low Very Low Very Low
antidepressant 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 5 100.00 Very High Very High Very High
Pheochromocytoma 4 80.56 Quite High
Death 7 77.68 Quite High
Neuroblastoma 2 61.92 Quite High
Cv Unclassified Under Development 1 58.68 Quite High
Brain Injury 1 57.88 Quite High
Disease 42 50.00 Quite Low
Parkinson's Disease 4 40.72 Quite Low
Drug Induced Neurotoxicity 2 36.40 Quite Low
Stroke 2 23.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This normally causes inhibition of the ubiquitin-proteosome complex and release of proapoptotic factors.36 Direct binding of the propargylamine moiety, however, prevents downstream activation of proapoptotic factors,37–40 partially via activation of anti-apoptotic factors including Bcl-2 and protein kinase C, and also by downregulation of proapoptotic catalysts including FAS and Bax protein families.36
Negative_regulation (downregulation) of FAS Negative_regulation (prevents) of Positive_regulation (activation) of Bcl-2 associated with kinase c and apoptosis
1) Confidence 0.01 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2695242 Disease Relevance 0.72 Pain Relevance 0.11

General Comments

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