INT273099

Context Info Confidence 0.21 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.07 Pain Relevance 0.18

extracellular region (Bdnf) plasma membrane (Dlg4) cytoplasmic membrane-bounded vesicle (Bdnf) protein complex assembly (Dlg4) response to stress (Dlg4) cytoplasm (Dlg4)

Bdnf (Rattus norvegicus) Dlg4 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Hippocampus 25 91.56 long-term potentiation 9 84.64 Glutamate receptor 1 5.00 anesthesia 1 5.00 amygdala 1 5.00 antagonist 1 5.00

Disease Link Frequency Relevance Heat Shock 4 73.24 Amnesia 3 5.00 Decapitation 2 5.00 Anxiety Disorder 2 5.00 Disease 1 5.00 Aging 1 5.00 Toxicity 1 5.00 Stress 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Our findings are consistent with others showing that, in vitro, BDNF upregulates local translation of PSD95 through mTOR pathway [76] and enhances the expression of GluR1 subunit of AMPA receptors via activation of mTOR [48].

BDNF Positive_regulation (upregulates) of Localization (translation) of PSD95

1) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0.07 Pain Relevance 0.18

General Comments

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