INT2731

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Context Info
Confidence 0.58
First Reported 1979
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 5.35
Pain Relevance 2.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (LTBR)
Anatomy Link Frequency
spinal cord 1
LTBR (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 19 100.00 Very High Very High Very High
Analgesic 2 99.48 Very High Very High Very High
Inflammation 33 98.96 Very High Very High Very High
Multiple sclerosis 130 98.28 Very High Very High Very High
Spinal cord 4 97.24 Very High Very High Very High
Etanercept 5 90.96 High High
Infliximab 12 85.00 Quite High
rheumatoid arthritis 13 84.40 Quite High
Adalimumab 75 81.52 Quite High
spinoreticular tract 4 75.00 Quite High
Disease Link Frequency Relevance Heat
Pain 11 100.00 Very High Very High Very High
Necrosis 4 100.00 Very High Very High Very High
Cancer 4 100.00 Very High Very High Very High
INFLAMMATION 32 98.96 Very High Very High Very High
Nociception 12 98.34 Very High Very High Very High
Multiple Sclerosis 138 98.28 Very High Very High Very High
Uveitis 52 97.84 Very High Very High Very High
Spinal Cord Injury 2 97.24 Very High Very High Very High
Disease 40 95.76 Very High Very High Very High
Syndrome 9 94.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This inhibition of the RIII reflex is not seen in tetraplegic patients with clinically complete spinal cord transection, suggesting that supraspinal structures are involved in this type of inhibition, mediated through 'Diffuse Noxious Inhibitory Controls' (DNIC).
Negative_regulation (inhibition) of RIII in spinal cord associated with spinal cord
1) Confidence 0.58 Published 1990 Journal Brain Section Abstract Doc Link 2397390 Disease Relevance 0.56 Pain Relevance 0.33
An inhibition of both pain sensation and RIII, Bi was observed in (1), while a facilitation of these parameters was noted in (2).
Negative_regulation (inhibition) of RIII associated with pain
2) Confidence 0.58 Published 1979 Journal Brain Res. Section Abstract Doc Link 509233 Disease Relevance 0.86 Pain Relevance 0.50
RESULTS: At baseline, slow distensions performed up to the pain threshold induced gradual inhibitions of the RIII reflex.
Negative_regulation (inhibitions) of RIII
3) Confidence 0.42 Published 2003 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 12622767 Disease Relevance 0 Pain Relevance 0
In the former, as in normal subjects, nociceptive electrical conditioning stimuli applied to the analgesic hand produced a profound inhibition of the RIII reflex followed by long-lasting after-effects.
Negative_regulation (inhibition) of RIII associated with nociception and analgesic
4) Confidence 0.38 Published 1990 Journal Brain Section Abstract Doc Link 2397390 Disease Relevance 0.85 Pain Relevance 0.51
inhibition with a p55 TNF- receptor fusion protein (TNFr-Ig) lowered the intraocular inflammation.
Negative_regulation (inhibition) of TNFr-Ig associated with inflammation
5) Confidence 0.03 Published 2010 Journal Middle East African Journal of Ophthalmology Section Body Doc Link PMC2991444 Disease Relevance 1.34 Pain Relevance 0.75
We found that the tumor necrosis factor receptor (TNFR) superfamily 19 gene (TNFRSF 19) was downregulated by 5.3-fold.
Negative_regulation (downregulated) of TNFR associated with necrosis and cancer
6) Confidence 0.02 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2227948 Disease Relevance 0.87 Pain Relevance 0.17
We found that the tumor necrosis factor receptor (TNFR) superfamily 19 gene (TNFRSF 19) was downregulated by 5.3-fold.
Negative_regulation (downregulated) of tumor necrosis factor receptor associated with necrosis and cancer
7) Confidence 0.02 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2227948 Disease Relevance 0.88 Pain Relevance 0.18

General Comments

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