INT273107

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Context Info
Confidence 0.26
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.09
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mtor) Golgi apparatus (Mtor) endoplasmic reticulum (Mtor)
cytoplasm (Mtor) cytosol (Mtor) extracellular region (Bdnf)
Anatomy Link Frequency
dorsal 2
Bdnf (Rattus norvegicus)
Mtor (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 25 70.24 Quite High
long-term potentiation 9 5.00 Very Low Very Low Very Low
Glutamate receptor 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
amygdala 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 2 93.72 High High
Shock 4 5.00 Very Low Very Low Very Low
Amnesia 3 5.00 Very Low Very Low Very Low
Decapitation 2 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low
Aging 1 5.00 Very Low Very Low Very Low
Toxicity 1 5.00 Very Low Very Low Very Low
Stress 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, BDNF ASO hindered LTM retention only when given into dorsal CA1 1 h after but not 2 h before training, suggesting that BDNF controls the biphasic requirement of mTOR during LTM consolidation through different mechanisms: an early one involving BDNF already available at the moment of training, and a late one, happening around 3 h post-training that needs de novo synthesis of this neurotrophin.


BDNF Regulation (controls) of Positive_regulation (requirement) of mTOR in dorsal
1) Confidence 0.26 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2695538 Disease Relevance 0.09 Pain Relevance 0.07

General Comments

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