INT273109

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.66
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.07
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gria1) extracellular region (Bdnf) endoplasmic reticulum (Gria1)
plasma membrane (Gria1) cytoplasmic membrane-bounded vesicle (Bdnf) protein complex (Gria1)
Anatomy Link Frequency
hippocampus 2
Bdnf (Rattus norvegicus)
Gria1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 50 99.84 Very High Very High Very High
long-term potentiation 18 84.64 Quite High
Glutamate receptor 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
amygdala 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 8 73.24 Quite High
Amnesia 6 5.00 Very Low Very Low Very Low
Decapitation 4 5.00 Very Low Very Low Very Low
Anxiety Disorder 4 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Aging 2 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our findings are consistent with others showing that, in vitro, BDNF upregulates local translation of PSD95 through mTOR pathway [76] and enhances the expression of GluR1 subunit of AMPA receptors via activation of mTOR [48].
BDNF Positive_regulation (enhances) of Gene_expression (expression) of GluR1
1) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0.07 Pain Relevance 0.19
Together, our findings show that the activated BDNF/mTOR pathway induced expression of GluR1 AMPA receptor subunit in hippocampus synaptic membranes, a key effector protein involved in stabilization of the memory traces is critical for LTM formation.


BDNF/mTOR Positive_regulation (induced) of Gene_expression (expression) of GluR1 AMPA receptor subunit in hippocampus associated with hippocampus
2) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.05

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox